| Name | PLK4 |
| ID | O00444 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 12-265 PROSITE-ProRule
Cryptic POLO box 1 (CPB1) 586-699 PROSITE-ProRule
Cryptic POLO box 2 (CPB2) 700-813 PROSITE-ProRule
POLO box 886-964 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK4 | PLK4 | Ser305 | SSTSISGsLFDKRRL | phosphorylation up-regulates | 20032307 | SIGNOR-162559 |
| PLK4 | CDC25C | – | phosphorylation up-regulates quantity | 35912011 | SIGNOR-280074 | |
| PLK4 | PCM1 | Ser372 | RRQAESLsLTREVSQ | phosphorylation up-regulates activity | 26755742 | SIGNOR-279556 |
| PLK4 | NEDD1 | Ser325 | PTTVNKRsVNVNAAS | phosphorylation up-regulates activity | 33351100 | SIGNOR-272996 |
| PLK4 | FBXW5 | Ser151 | SQFNKDDsLLLASGV | phosphorylation down-regulates activity | 21725316 | SIGNOR-275476 |
| PLK4 | TUBGCP6 | Ser1060 | HGHVSDAsIRVGENV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262900 |
| PLK4 | TUBGCP6 | Ser1087 | HGHVSNAsISLGESV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262901 |
| PLK4 | TUBGCP6 | Ser1114 | HGHVSNAsIRVGENV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262902 |
| PLK4 | TUBGCP6 | Ser1168 | HGHVSDAsISLGESV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262903 |
| PLK4 | TUBGCP6 | Ser1176 | ISLGESVsDMAPARP | phosphorylation up-regulates activity | 22302995 | SIGNOR-262904 |
| PLK4 | TUBGCP6 | Ser1195 | HGHVSDAsISLGESV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262905 |
| PLK4 | TUBGCP6 | Ser1249 | HGHVSDAsISLGEPV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262906 |
| PLK4 | TUBGCP6 | Ser1437 | RYPDSYEsMSEPPIA | phosphorylation up-regulates activity | 22302995 | SIGNOR-262907 |
| PLK4 | TUBGCP6 | Ser1465 | PVDPQVQsAADETAV | phosphorylation up-regulates activity | 22302995 | SIGNOR-262908 |
| PLK4 | TUBGCP6 | Ser392 | VSGASPEsISSLLSE | phosphorylation up-regulates activity | 22302995 | SIGNOR-262909 |
| PLK4 | CENPJ | Ser595 | ISFSSNSsFVLKILE | phosphorylation up-regulates | 20531387 | SIGNOR-166007 |
| PLK4 | CEP131 | Ser78 | NNLRRSNsTTQVSQP | phosphorylation up-regulates activity | 30804208 | SIGNOR-280075 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK4 | phosphorylation up-regulates → | PLK4 PSer305 | phosphorylation up-regulates → | PLK4 | 20032307 | SIGNOR-162559 |
| PLK4 | phosphorylation up-regulates → | PCM1 PSer372 | phosphorylation up-regulates → | PCM1 | 26755742 | SIGNOR-279556 |
| PLK4 | phosphorylation up-regulates → | NEDD1 PSer325 | phosphorylation up-regulates → | NEDD1 | 33351100 | SIGNOR-272996 |
| PLK4 | phosphorylation up-regulates → | FBXW5 PSer151 | phosphorylation down-regulates ⊣ | FBXW5 | 21725316 | SIGNOR-275476 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1060 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262900 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1087 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262901 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1114 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262902 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1168 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262903 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1176 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262904 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1195 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262905 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1249 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262906 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1437 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262907 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer1465 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262908 |
| PLK4 | phosphorylation up-regulates → | TUBGCP6 PSer392 | phosphorylation up-regulates → | TUBGCP6 | 22302995 | SIGNOR-262909 |
| PLK4 | phosphorylation up-regulates → | CENPJ PSer595 | phosphorylation up-regulates → | CENPJ | 20531387 | SIGNOR-166007 |
| PLK4 | phosphorylation up-regulates → | CEP131 PSer78 | phosphorylation up-regulates → | CEP131 | 30804208 | SIGNOR-280075 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK4 | phosphorylation → up-regulates | PLK4 | SIGNOR-162559 |
| PLK4 | phosphorylation → up-regulates quantity | CDC25C | SIGNOR-280074 |
| PLK4 | phosphorylation → up-regulates activity | PCM1 | SIGNOR-279556 |
| PLK4 | phosphorylation → up-regulates activity | NEDD1 | SIGNOR-272996 |
| PLK4 | phosphorylation → down-regulates activity | FBXW5 | SIGNOR-275476 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262900 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262901 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262902 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262903 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262904 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262905 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262906 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262907 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262908 |
| PLK4 | phosphorylation → up-regulates activity | TUBGCP6 | SIGNOR-262909 |
| PLK4 | phosphorylation → up-regulates | CENPJ | SIGNOR-166007 |
| PLK4 | phosphorylation → up-regulates activity | CEP131 | SIGNOR-280075 |