| Name | DDX3X |
| ID | O00571 |
| Role | substrate |
| Enzymatic Domains |
Helicase ATP-binding 211-403 PROSITE-ProRule
Helicase C-terminal 414-575 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TBK1 | DDX3X | – | phosphorylation up-regulates activity | 18583960 | SIGNOR-278997 | |
| CyclinB/CDK1 | DDX3X | Thr323 | GCHLLVAtPGRLVDM | phosphorylation down-regulates | 16280325 | SIGNOR-216872 |
| CDK1 | DDX3X | Thr323 | GCHLLVAtPGRLVDM | phosphorylation down-regulates | 16280325 | SIGNOR-141569 |
| CyclinB/CDK1 | DDX3X | Thr204 | LTRYTRPtPVQKHAI | phosphorylation down-regulates | 16280325 | SIGNOR-216868 |
| CDK1 | DDX3X | Thr204 | LTRYTRPtPVQKHAI | phosphorylation down-regulates | 16280325 | SIGNOR-141565 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | DDX3X PThr323 | phosphorylation down-regulates ⊣ | DDX3X | 16280325 | SIGNOR-216872 |
| CDK1 | phosphorylation up-regulates → | DDX3X PThr323 | phosphorylation down-regulates ⊣ | DDX3X | 16280325 | SIGNOR-141569 |
| CyclinB/CDK1 | phosphorylation up-regulates → | DDX3X PThr204 | phosphorylation down-regulates ⊣ | DDX3X | 16280325 | SIGNOR-216868 |
| CDK1 | phosphorylation up-regulates → | DDX3X PThr204 | phosphorylation down-regulates ⊣ | DDX3X | 16280325 | SIGNOR-141565 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TBK1 | phosphorylation → up-regulates activity | DDX3X | SIGNOR-278997 |
| CyclinB/CDK1 | phosphorylation down-regulates | DDX3X | SIGNOR-216872 |
| CDK1 | phosphorylation down-regulates | DDX3X | SIGNOR-141569 |
| CyclinB/CDK1 | phosphorylation down-regulates | DDX3X | SIGNOR-216868 |
| CDK1 | phosphorylation down-regulates | DDX3X | SIGNOR-141565 |