Entity Details

Name PPP6C
ID O00743
Role phosphatase
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PPP6CMAP3K7Thr187CDIQTHMtNNKGSAAdephosphorylation
down-regulates		17079228SIGNOR-150408
PPP6CMAP3K7Thr187CDIQTHMtNNKGSAAdephosphorylation
down-regulates activity		17079228SIGNOR-248292
PPP6CPRKDC–dephosphorylation
up-regulates activity		19198648SIGNOR-277164
PPP6CCGASSer435KHLDKFSsYHVKTAFdephosphorylation
down-regulates activity		32474700SIGNOR-276990
PPP6CAGO2Ser824LVDKEHDsAEGSHTSdephosphorylation
up-regulates activity		28114302SIGNOR-276516
PPP6CAGO2Ser828EHDSAEGsHTSGQSNdephosphorylation
up-regulates activity		28114302SIGNOR-276517
PPP6CAGO2Ser831SAEGSHTsGQSNGRDdephosphorylation
up-regulates activity		28114302SIGNOR-276513
PPP6CAGO2Ser834GSHTSGQsNGRDHQAdephosphorylation
up-regulates activity		28114302SIGNOR-276514
PPP6CAGO2Thr830DSAEGSHtSGQSNGRdephosphorylation
up-regulates activity		28114302SIGNOR-276515
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PPP6Cdephosphorylation
down-regulates
⊣
MAP3K7
PThr187		dephosphorylation
up-regulates
→		MAP3K717079228SIGNOR-150408
PPP6Cdephosphorylation
down-regulates
⊣
MAP3K7
PThr187		dephosphorylation
up-regulates
→		MAP3K717079228SIGNOR-248292
PPP6Cdephosphorylation
down-regulates
⊣
CGAS
PSer435		dephosphorylation
up-regulates
→		CGAS32474700SIGNOR-276990
PPP6Cdephosphorylation
down-regulates
⊣
AGO2
PSer824		dephosphorylation
down-regulates
⊣		AGO228114302SIGNOR-276516
PPP6Cdephosphorylation
down-regulates
⊣
AGO2
PSer828		dephosphorylation
down-regulates
⊣		AGO228114302SIGNOR-276517
PPP6Cdephosphorylation
down-regulates
⊣
AGO2
PSer831		dephosphorylation
down-regulates
⊣		AGO228114302SIGNOR-276513
PPP6Cdephosphorylation
down-regulates
⊣
AGO2
PSer834		dephosphorylation
down-regulates
⊣		AGO228114302SIGNOR-276514
PPP6Cdephosphorylation
down-regulates
⊣
AGO2
PThr830		dephosphorylation
down-regulates
⊣		AGO228114302SIGNOR-276515
Regulator Mechanism/Effect Target SIGNOR-ID
PPP6Cdephosphorylation
img/direct_inhibition.png
down-regulates 		MAP3K7SIGNOR-150408
PPP6Cdephosphorylation
→
down-regulates activity 		MAP3K7SIGNOR-248292
PPP6Cdephosphorylation
→
up-regulates activity 		PRKDCSIGNOR-277164
PPP6Cdephosphorylation
→
down-regulates activity 		CGASSIGNOR-276990
PPP6Cdephosphorylation
→
up-regulates activity 		AGO2SIGNOR-276516
PPP6Cdephosphorylation
→
up-regulates activity 		AGO2SIGNOR-276517
PPP6Cdephosphorylation
→
up-regulates activity 		AGO2SIGNOR-276513
PPP6Cdephosphorylation
→
up-regulates activity 		AGO2SIGNOR-276514
PPP6Cdephosphorylation
→
up-regulates activity 		AGO2SIGNOR-276515