| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | SH2B2 | Ser598 | SARSRSNsAERLLEA | phosphorylation up-regulates activity | 16141217 | SIGNOR-248042 |
| AKT1 | SH2B2 | Ser598 | SARSRSNsAERLLEA | phosphorylation up-regulates activity | 16141217 | SIGNOR-252557 |
| AKT | SH2B2 | Ser598 | SARSRSNsAERLLEA | phosphorylation unknown | 16141217 | SIGNOR-251487 |
| AKT1 | SH2B2 | Ser598 | SARSRSNsAERLLEA | phosphorylation unknown | 16141217 | SIGNOR-252577 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | SH2B2 PSer598 | phosphorylation up-regulates → | SH2B2 | 16141217 | SIGNOR-248042 |
| AKT1 | phosphorylation up-regulates → | SH2B2 PSer598 | phosphorylation up-regulates → | SH2B2 | 16141217 | SIGNOR-252557 |
| AKT | phosphorylation up-regulates → | SH2B2 PSer598 | phosphorylation down-regulates ⊣ | SH2B2 | 16141217 | SIGNOR-251487 |
| AKT1 | phosphorylation up-regulates → | SH2B2 PSer598 | phosphorylation down-regulates ⊣ | SH2B2 | 16141217 | SIGNOR-252577 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates activity | SH2B2 | SIGNOR-248042 |
| AKT1 | phosphorylation → up-regulates activity | SH2B2 | SIGNOR-252557 |
| AKT | phosphorylation → unknown | SH2B2 | SIGNOR-251487 |
| AKT1 | phosphorylation → unknown | SH2B2 | SIGNOR-252577 |
