Entity Details

Name PTPRT
ID O14522
Role phosphatase
Enzymatic Domains
MAM 30-191
PROSITE-ProRule
Ig-like C2-type 193-284
Fibronectin type-III 1 291-384
PROSITE-ProRule
Fibronectin type-III 2 389-483
PROSITE-ProRule
Fibronectin type-III 3 484-590
PROSITE-ProRule
Fibronectin type-III 4 591-726
PROSITE-ProRule
Tyrosine-protein phosphatase 1 889-1143
PROSITE-ProRule
Tyrosine-protein phosphatase 2 1175-1437
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPRTSTAT3Tyr705DPGSAAPyLKTKFICdephosphorylation
down-regulates activity		17360477SIGNOR-263981
PTPRTSTAT3–dephosphorylation
down-regulates activity		17360477SIGNOR-277043
PTPRTPXNTyr88PQSSSPVyGSSAKTSdephosphorylation
down-regulates activity		27447856SIGNOR-263978
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPRTdephosphorylation
down-regulates
⊣
STAT3
PTyr705		dephosphorylation
up-regulates
→		STAT317360477SIGNOR-263981
PTPRTdephosphorylation
down-regulates
⊣
PXN
PTyr88		dephosphorylation
up-regulates
→		PXN27447856SIGNOR-263978
Regulator Mechanism/Effect Target SIGNOR-ID
PTPRTdephosphorylation
→
down-regulates activity 		STAT3SIGNOR-263981
PTPRTdephosphorylation
→
down-regulates activity 		STAT3SIGNOR-277043
PTPRTdephosphorylation
→
down-regulates activity 		PXNSIGNOR-263978