Entity Details

Name KCNK3
ID O14649
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PRKCEKCNK3Thr383TGLHSLStFRGLMKRphosphorylation
down-regulates activity		23229553SIGNOR-276431
ROCK1KCNK3Ser393GLMKRRSsVphosphorylation
up-regulates activity		21838752SIGNOR-176029
ROCK1KCNK3Ser336IPRDLSTsDTCVEQSphosphorylation
down-regulates		21838752SIGNOR-176025
PRKACAKCNK3Ser393GLMKRRSsVphosphorylation
up-regulates activity		21357689SIGNOR-172430
RPS6KA3KCNK3Ser393GLMKRRSsVphosphorylation
up-regulates activity		21357689SIGNOR-172470
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PRKCEphosphorylation
up-regulates
→
KCNK3
PThr383		phosphorylation
down-regulates
⊣		KCNK323229553SIGNOR-276431
ROCK1phosphorylation
up-regulates
→
KCNK3
PSer393		phosphorylation
up-regulates
→		KCNK321838752SIGNOR-176029
ROCK1phosphorylation
up-regulates
→
KCNK3
PSer336		phosphorylation
down-regulates
⊣		KCNK321838752SIGNOR-176025
PRKACAphosphorylation
up-regulates
→
KCNK3
PSer393		phosphorylation
up-regulates
→		KCNK321357689SIGNOR-172430
RPS6KA3phosphorylation
up-regulates
→
KCNK3
PSer393		phosphorylation
up-regulates
→		KCNK321357689SIGNOR-172470
Regulator Mechanism/Effect Target SIGNOR-ID
PRKCEphosphorylation
→
down-regulates activity 		KCNK3SIGNOR-276431
ROCK1phosphorylation
→
up-regulates activity 		KCNK3SIGNOR-176029
ROCK1phosphorylation
img/direct_inhibition.png
down-regulates 		KCNK3SIGNOR-176025
PRKACAphosphorylation
→
up-regulates activity 		KCNK3SIGNOR-172430
RPS6KA3phosphorylation
→
up-regulates activity 		KCNK3SIGNOR-172470