| Name | IRS4 |
| ID | O14654 |
| Role | substrate |
| Enzymatic Domains |
PH 78-199 PROSITE-ProRule
IRS-type PTB 231-335 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1G2 | IRS4 | Ser859 | KDAASKPsGEGSFSK | phosphorylation down-regulates quantity by destabilization | 30026872 | SIGNOR-277615 |
| IGF1R | IRS4 | – | phosphorylation up-regulates | 9553137 | SIGNOR-56604 | |
| INSR | IRS4 | – | phosphorylation up-regulates activity | 25905389 | SIGNOR-217897 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1G2 | phosphorylation up-regulates → | IRS4 PSer859 | phosphorylation down-regulates ⊣ | IRS4 | 30026872 | SIGNOR-277615 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1G2 | phosphorylation down-regulates quantity by destabilization | IRS4 | SIGNOR-277615 |
| IGF1R | phosphorylation → up-regulates | IRS4 | SIGNOR-56604 |
| INSR | phosphorylation → up-regulates activity | IRS4 | SIGNOR-217897 |