| Name | MAP2K7 |
| ID | O14733 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 120-380 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K7 | MAPK13 | Thr180 | RHADAEMtGYVVTRW | phosphorylation up-regulates activity | 10066767 | SIGNOR-273954 |
| MAP2K7 | MAPK13 | Tyr182 | ADAEMTGyVVTRWYR | phosphorylation up-regulates activity | 10066767 | SIGNOR-273953 |
| MAP2K7 | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 17360977 | SIGNOR-217920 |
| MAP2K7 | MAPK8 | Thr183 | AGTSFMMtPYVVTRY | phosphorylation up-regulates | 11062067 | SIGNOR-83736 |
| MAP2K7 | MAPK8 | Thr183 | AGTSFMMtPYVVTRY | phosphorylation up-regulates | 9312068 | SIGNOR-51199 |
| MAP2K7 | MAPK8 | Tyr185 | TSFMMTPyVVTRYYR | phosphorylation up-regulates | 9312068 | SIGNOR-51203 |
| MAP2K7 | MAPK9 | Thr183 | ACTNFMMtPYVVTRY | phosphorylation up-regulates | 11062067 | SIGNOR-83744 |
| MAP2K7 | MAPK9 | Tyr185 | TNFMMTPyVVTRYYR | phosphorylation up-regulates | 11062067 | SIGNOR-83748 |
| MAP2K7 | MAPK9 | Thr183 | ACTNFMMtPYVVTRY | phosphorylation up-regulates | 9890973 | SIGNOR-63976 |
| MAP2K7 | MAPK9 | Ser407 | STEQTLAsDTDSSLD | phosphorylation up-regulates activity | 11062067 | SIGNOR-251416 |
| MAP2K7 | MAPK9 | Thr183 | ACTNFMMtPYVVTRY | phosphorylation up-regulates activity | 11062067 | SIGNOR-251417 |
| MAP2K7 | MAPK9 | Thr404 | SSMSTEQtLASDTDS | phosphorylation up-regulates activity | 11062067 | SIGNOR-251418 |
| MAP2K7 | MAPK10 | – | phosphorylation up-regulates | 11062067 | SIGNOR-83732 | |
| MAP2K7 | MAPK10 | Thr221 | AGTSFMMtPYVVTRY | phosphorylation up-regulates | 15911620 | SIGNOR-137609 |
| MAP2K7 | MAPK10 | – | phosphorylation up-regulates | 9890973 | SIGNOR-63972 | |
| MAP2K7 | MAPK10 | Thr221 | AGTSFMMtPYVVTRY | phosphorylation up-regulates activity | 10715136 | SIGNOR-251422 |
| MAP2K7 | FADD | Ser194 | QNRSGAMsPMSWNSD | phosphorylation down-regulates activity | 15001534 | SIGNOR-123164 |
| MAP2K7 | JNK | – | phosphorylation up-regulates activity | 11062067 | SIGNOR-83725 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K7 | phosphorylation up-regulates → | MAPK13 PThr180 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273954 |
| MAP2K7 | phosphorylation up-regulates → | MAPK13 PTyr182 | phosphorylation up-regulates → | MAPK13 | 10066767 | SIGNOR-273953 |
| MAP2K7 | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 17360977 | SIGNOR-217920 |
| MAP2K7 | phosphorylation up-regulates → | MAPK8 PThr183 | phosphorylation up-regulates → | MAPK8 | 11062067 | SIGNOR-83736 |
| MAP2K7 | phosphorylation up-regulates → | MAPK8 PThr183 | phosphorylation up-regulates → | MAPK8 | 9312068 | SIGNOR-51199 |
| MAP2K7 | phosphorylation up-regulates → | MAPK8 PTyr185 | phosphorylation up-regulates → | MAPK8 | 9312068 | SIGNOR-51203 |
| MAP2K7 | phosphorylation up-regulates → | MAPK9 PThr183 | phosphorylation up-regulates → | MAPK9 | 11062067 | SIGNOR-83744 |
| MAP2K7 | phosphorylation up-regulates → | MAPK9 PTyr185 | phosphorylation up-regulates → | MAPK9 | 11062067 | SIGNOR-83748 |
| MAP2K7 | phosphorylation up-regulates → | MAPK9 PThr183 | phosphorylation up-regulates → | MAPK9 | 9890973 | SIGNOR-63976 |
| MAP2K7 | phosphorylation up-regulates → | MAPK9 PSer407 | phosphorylation up-regulates → | MAPK9 | 11062067 | SIGNOR-251416 |
| MAP2K7 | phosphorylation up-regulates → | MAPK9 PThr183 | phosphorylation up-regulates → | MAPK9 | 11062067 | SIGNOR-251417 |
| MAP2K7 | phosphorylation up-regulates → | MAPK9 PThr404 | phosphorylation up-regulates → | MAPK9 | 11062067 | SIGNOR-251418 |
| MAP2K7 | phosphorylation up-regulates → | MAPK10 PThr221 | phosphorylation up-regulates → | MAPK10 | 15911620 | SIGNOR-137609 |
| MAP2K7 | phosphorylation up-regulates → | MAPK10 PThr221 | phosphorylation up-regulates → | MAPK10 | 10715136 | SIGNOR-251422 |
| MAP2K7 | phosphorylation up-regulates → | FADD PSer194 | phosphorylation down-regulates ⊣ | FADD | 15001534 | SIGNOR-123164 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K7 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273954 |
| MAP2K7 | phosphorylation → up-regulates activity | MAPK13 | SIGNOR-273953 |
| MAP2K7 | phosphorylation → down-regulates activity | IRS1 | SIGNOR-217920 |
| MAP2K7 | phosphorylation → up-regulates | MAPK8 | SIGNOR-83736 |
| MAP2K7 | phosphorylation → up-regulates | MAPK8 | SIGNOR-51199 |
| MAP2K7 | phosphorylation → up-regulates | MAPK8 | SIGNOR-51203 |
| MAP2K7 | phosphorylation → up-regulates | MAPK9 | SIGNOR-83744 |
| MAP2K7 | phosphorylation → up-regulates | MAPK9 | SIGNOR-83748 |
| MAP2K7 | phosphorylation → up-regulates | MAPK9 | SIGNOR-63976 |
| MAP2K7 | phosphorylation → up-regulates activity | MAPK9 | SIGNOR-251416 |
| MAP2K7 | phosphorylation → up-regulates activity | MAPK9 | SIGNOR-251417 |
| MAP2K7 | phosphorylation → up-regulates activity | MAPK9 | SIGNOR-251418 |
| MAP2K7 | phosphorylation → up-regulates | MAPK10 | SIGNOR-83732 |
| MAP2K7 | phosphorylation → up-regulates | MAPK10 | SIGNOR-137609 |
| MAP2K7 | phosphorylation → up-regulates | MAPK10 | SIGNOR-63972 |
| MAP2K7 | phosphorylation → up-regulates activity | MAPK10 | SIGNOR-251422 |
| MAP2K7 | phosphorylation → down-regulates activity | FADD | SIGNOR-123164 |
| MAP2K7 | phosphorylation → up-regulates activity | JNK | SIGNOR-83725 |