Entity Details

Name PRMT5
ID O14744
Role substrate
Enzymatic Domains
SAM-dependent MTase PRMT-type 308-615
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
JAK2PRMT5Tyr297NRPPPNAyELFAKGYphosphorylation
down-regulates		21316606SIGNOR-171994
SRCPRMT5Tyr324DNLESQTyEVFEKDPphosphorylation
down-regulates activity		32759981SIGNOR-277523
STK11PRMT5Thr144VLTNHIHtGHHSSMFphosphorylation
up-regulates activity		30289978SIGNOR-277412
STK11PRMT5Thr139TNLARVLtNHIHTGHphosphorylation
up-regulates activity		30289978SIGNOR-277411
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
JAK2phosphorylation
up-regulates
→
PRMT5
PTyr297		phosphorylation
down-regulates
⊣		PRMT521316606SIGNOR-171994
SRCphosphorylation
up-regulates
→
PRMT5
PTyr324		phosphorylation
down-regulates
⊣		PRMT532759981SIGNOR-277523
STK11phosphorylation
up-regulates
→
PRMT5
PThr144		phosphorylation
up-regulates
→		PRMT530289978SIGNOR-277412
STK11phosphorylation
up-regulates
→
PRMT5
PThr139		phosphorylation
up-regulates
→		PRMT530289978SIGNOR-277411
Regulator Mechanism/Effect Target SIGNOR-ID
JAK2phosphorylation
img/direct_inhibition.png
down-regulates 		PRMT5SIGNOR-171994
SRCphosphorylation
→
down-regulates activity 		PRMT5SIGNOR-277523
STK11phosphorylation
→
up-regulates activity 		PRMT5SIGNOR-277412
STK11phosphorylation
→
up-regulates activity 		PRMT5SIGNOR-277411