| Name | CHEK1 |
| ID | O14757 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 9-265 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | WEE1 | – | phosphorylation up-regulates | 20068082 | SIGNOR-163164 | |
| CHEK1 | TP53 | Ser366 | PGGSRAHsSHLKSKK | phosphorylation up-regulates activity | 15659650 | SIGNOR-217853 |
| CHEK1 | BUB1B | – | phosphorylation up-regulates activity | 19778378 | SIGNOR-280223 | |
| CHEK1 | FOXM1 | – | phosphorylation up-regulates activity | 23706767 | SIGNOR-280224 | |
| CHEK1 | RELA | Thr505 | EAITRLVtGAQRPPD | phosphorylation up-regulates activity | 15775976 | SIGNOR-280225 |
| CHEK1 | TRIM28 | Ser473 | SGVKRSRsGEGEVSG | phosphorylation up-regulates activity | 21851590 | SIGNOR-280226 |
| CHEK1 | PLK1 | Ser529 | ILHLSNGsVQINFFQ | phosphorylation down-regulates activity | 37596441 | SIGNOR-277913 |
| CHEK1 | SNCB | Tyr127 | EDPPQEEyQEYEPEA | phosphorylation unknown | 21699177 | SIGNOR-174590 |
| CHEK1 | FANCE | Thr346 | LGLLRLCtWLLALSP | phosphorylation up-regulates | 17296736 | SIGNOR-153027 |
| CHEK1 | DIAPH1 | – | phosphorylation down-regulates activity | 28697335 | SIGNOR-279026 | |
| CHEK1 | CDC25A | Ser279 | VLKRPERsQEESPPG | phosphorylation down-regulates | 20068082 | SIGNOR-163142 |
| CHEK1 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates activity | 15659650 | SIGNOR-217791 |
| CHEK1 | CDC25A | Ser178 | LFTQRQNsAPARMLS | phosphorylation down-regulates | 20068082 | SIGNOR-163138 |
| CHEK1 | RAD9A | – | phosphorylation up-regulates activity | 26658951 | SIGNOR-279503 | |
| CHEK1 | SYK | Ser295 | GIISRIKsYSFPKPG | phosphorylation down-regulates | 22585575 | SIGNOR-197528 |
| CHEK1 | RHOB | Thr173 | GVREVFEtATRAALQ | phosphorylation up-regulates activity | 30297842 | SIGNOR-279727 |
| CHEK1 | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates activity | 16163388 | SIGNOR-250770 |
| CHEK1 | BAD | – | phosphorylation down-regulates activity | 15736430 | SIGNOR-279159 | |
| CHEK1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation down-regulates quantity by destabilization | 25486478 | SIGNOR-279324 |
| CHEK1 | PLK1 | Ser137 | LELCRRRsLLELHKR | phosphorylation up-regulates activity | 34197606 | SIGNOR-279502 |
| CHEK1 | BLM | Ser646 | LKHERFQsLSFPHTK | phosphorylation up-regulates | 20719863 | SIGNOR-167534 |
| CHEK1 | TP53 | Thr18 | EPPLSQEtFSDLWKL | phosphorylation up-regulates activity | 15659650 | SIGNOR-217803 |
| CHEK1 | MAP4 | Thr521 | MALGKDVtPPPETEV | phosphorylation down-regulates quantity by destabilization | 36991467 | SIGNOR-277846 |
| CHEK1 | SRC | Ser51 | ADGHRGPsAAFAPAA | phosphorylation up-regulates activity | 29954829 | SIGNOR-278332 |
| CHEK1 | CLSPN | Thr916 | DELLDLCtGKFTSQA | phosphorylation up-regulates | 16963448 | SIGNOR-149411 |
| CHEK1 | RASSF1 | Ser188 | PSSKKPPsLQDARRG | phosphorylation unknown | 24197116 | SIGNOR-203144 |
| CHEK1 | WEE1 | Ser642 | KKMNRSVsLTIY | phosphorylation up-regulates activity | 28396830 | SIGNOR-279027 |
| CHEK1 | E2F7 | – | phosphorylation down-regulates activity | 29363506 | SIGNOR-279692 | |
| CHEK1 | RHOB | Thr175 | REVFETAtRAALQKR | phosphorylation up-regulates activity | 30297842 | SIGNOR-279728 |
| CHEK1 | CDC7 | – | phosphorylation up-regulates | 20068082 | SIGNOR-163161 | |
| CHEK1 | CDH1 | – | phosphorylation down-regulates activity | 32345958 | SIGNOR-278396 | |
| CHEK1 | PPP1R12A | Ser20 | QLKRWIGsETDLEPP | phosphorylation down-regulates quantity by destabilization | 29262732 | SIGNOR-277870 |
| CHEK1 | FANCE | Ser374 | LFLGRILsLTSSASR | phosphorylation up-regulates | 17296736 | SIGNOR-153023 |
| CHEK1 | PLK1 | Thr539 | INFFQDHtKLILCPL | phosphorylation down-regulates activity | 37596441 | SIGNOR-277914 |
| CHEK1 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates activity | 15659650 | SIGNOR-217799 |
| CHEK1 | TP53 | Ser378 | SKKGQSTsRHKKLMF | phosphorylation up-regulates activity | 15659650 | SIGNOR-217857 |
| CHEK1 | NEK11 | Ser273 | SMLNKNPsLRPSAIE | phosphorylation up-regulates | 19734889 | SIGNOR-187863 |
| CHEK1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation down-regulates quantity by destabilization | 25486478 | SIGNOR-279325 |
| CHEK1 | CDC25A | Ser76 | SNLQRMGsSESTDSG | phosphorylation down-regulates | 20068082 | SIGNOR-163150 |
| CHEK1 | E2F3 | Ser124 | PALGRGGsGGGGGPP | phosphorylation up-regulates | 19917728 | SIGNOR-161758 |
| CHEK1 | ERRFI1 | Ser251 | RRLRRSHsGPAGSFN | phosphorylation down-regulates activity | 22505024 | SIGNOR-276411 |
| CHEK1 | CDC25A | Thr507 | KFRTKSRtWAGEKSK | phosphorylation down-regulates | 20068082 | SIGNOR-163154 |
| CHEK1 | Histone H3 | – | phosphorylation down-regulates activity | 18243098 | SIGNOR-265326 | |
| CHEK1 | TICRR | – | phosphorylation down-regulates activity | 25557548 | SIGNOR-278924 | |
| CHEK1 | PABIR1 | Ser37 | GGLRRSNsAPLIHGL | phosphorylation down-regulates activity | 33108758 | SIGNOR-266380 |
| CHEK1 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation down-regulates quantity by destabilization | 20068082 | SIGNOR-163158 |
| CHEK1 | ASF1A | Ser166 | KLEDAESsNPNLQSL | phosphorylation up-regulates activity | 33503415 | SIGNOR-277620 |
| CHEK1 | CHEK1 | Ser296 | GFSKHIQsNLDFSPV | phosphorylation up-regulates activity | 23068608 | SIGNOR-217904 |
| CHEK1 | E2F8 | – | phosphorylation down-regulates activity | 29363506 | SIGNOR-279693 | |
| CHEK1 | CDC25A | Ser124 | PALKRSHsDSLDHDI | phosphorylation down-regulates | 20068082 | SIGNOR-163134 |
| CHEK1 | E2F6 | Ser52 | EDNVQYVsMRKALKV | phosphorylation down-regulates activity | 23954429 | SIGNOR-266371 |
| CHEK1 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation up-regulates activity | 34197606 | SIGNOR-279501 |
| CHEK1 | TLK2 | Ser750 | PHIRKSVsTSSPAGA | phosphorylation down-regulates activity | 12955071 | SIGNOR-262740 |
| CHEK1 | NFKB1 | Ser328 | INITKPAsVFVQLRR | phosphorylation down-regulates | 22152481 | SIGNOR-195208 |
| CHEK1 | BLM | Thr182 | SHFVRVStAQKSKKG | phosphorylation down-regulates quantity by destabilization | 26028025 | SIGNOR-276909 |
| CHEK1 | SETMAR | Ser508 | LYDNRRRsAQWLDQE | phosphorylation down-regulates activity | 25024738 | SIGNOR-273610 |
| CHEK1 | RAD51 | Thr309 | LRKGRGEtRICKIYD | phosphorylation up-regulates | 15665856 | SIGNOR-133375 |
| CHEK1 | CDC25B | Ser230 | AFAQRPSsAPDLMCL | phosphorylation down-regulates activity | 17003105 | SIGNOR-149898 |
| CHEK1 | FANCD2 | Ser331 | KSKGRASsSGNQESS | phosphorylation up-regulates activity | 19861535 | SIGNOR-107042 |
| CHEK1 | TLK1 | Ser743 | PHMRRSNsSGNLHMA | phosphorylation down-regulates | 12660173 | SIGNOR-99653 |
| CHEK1 | FANCD2 | Ser331 | KSKGRASsSGNQESS | phosphorylation up-regulates activity | 19861535 | SIGNOR-263252 |
| CHEK1 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 18356162 | SIGNOR-178067 |
| CHEK1 | E2F6 | Ser12 | RPARKLPsLLLDPTE | phosphorylation down-regulates activity | 23954429 | SIGNOR-266370 |
| CHEK1 | CHEK1 | Ser296 | GFSKHIQsNLDFSPV | phosphorylation up-regulates activity | 15707391 | SIGNOR-219240 |
| CHEK1 | RB1 | Ser612 | MYLSPVRsPKKKGST | phosphorylation up-regulates activity | 17380128 | SIGNOR-153904 |
| CHEK1 | TP53 | Thr387 | HKKLMFKtEGPDSD | phosphorylation up-regulates activity | 15659650 | SIGNOR-217861 |
| CHEK1 | H3-3A | Thr12 | KQTARKStGGKAPRK | phosphorylation down-regulates activity | 18243098 | SIGNOR-160557 |
| CHEK1 | TP73 | Ser47 | EVVGGTDsSMDVFHL | phosphorylation up-regulates | 14585975 | SIGNOR-118913 |
| CHEK1 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 15659650 | SIGNOR-217795 |
| CHEK1 | NEK6 | – | phosphorylation down-regulates activity | 18728393 | SIGNOR-279403 | |
| CHEK1 | AURKB | Ser331 | HPWVRANsRRVLPPS | phosphorylation up-regulates | 17276342 | SIGNOR-152926 |
| CHEK1 | CDC25A | Ser293 | GSTKRRKsMSGASPK | phosphorylation down-regulates | 20068082 | SIGNOR-163146 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | TP53 PSer366 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217853 |
| CHEK1 | phosphorylation up-regulates → | RELA PThr505 | phosphorylation up-regulates → | RELA | 15775976 | SIGNOR-280225 |
| CHEK1 | phosphorylation up-regulates → | TRIM28 PSer473 | phosphorylation up-regulates → | TRIM28 | 21851590 | SIGNOR-280226 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PSer529 | phosphorylation down-regulates ⊣ | PLK1 | 37596441 | SIGNOR-277913 |
| CHEK1 | phosphorylation up-regulates → | SNCB PTyr127 | phosphorylation down-regulates ⊣ | SNCB | 21699177 | SIGNOR-174590 |
| CHEK1 | phosphorylation up-regulates → | FANCE PThr346 | phosphorylation up-regulates → | FANCE | 17296736 | SIGNOR-153027 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer279 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163142 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217791 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer178 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163138 |
| CHEK1 | phosphorylation up-regulates → | SYK PSer295 | phosphorylation down-regulates ⊣ | SYK | 22585575 | SIGNOR-197528 |
| CHEK1 | phosphorylation up-regulates → | RHOB PThr173 | phosphorylation up-regulates → | RHOB | 30297842 | SIGNOR-279727 |
| CHEK1 | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16163388 | SIGNOR-250770 |
| CHEK1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation down-regulates ⊣ | CDKN1A | 25486478 | SIGNOR-279324 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PSer137 | phosphorylation up-regulates → | PLK1 | 34197606 | SIGNOR-279502 |
| CHEK1 | phosphorylation up-regulates → | BLM PSer646 | phosphorylation up-regulates → | BLM | 20719863 | SIGNOR-167534 |
| CHEK1 | phosphorylation up-regulates → | TP53 PThr18 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217803 |
| CHEK1 | phosphorylation up-regulates → | MAP4 PThr521 | phosphorylation down-regulates ⊣ | MAP4 | 36991467 | SIGNOR-277846 |
| CHEK1 | phosphorylation up-regulates → | SRC PSer51 | phosphorylation up-regulates → | SRC | 29954829 | SIGNOR-278332 |
| CHEK1 | phosphorylation up-regulates → | CLSPN PThr916 | phosphorylation up-regulates → | CLSPN | 16963448 | SIGNOR-149411 |
| CHEK1 | phosphorylation up-regulates → | RASSF1 PSer188 | phosphorylation down-regulates ⊣ | RASSF1 | 24197116 | SIGNOR-203144 |
| CHEK1 | phosphorylation up-regulates → | WEE1 PSer642 | phosphorylation up-regulates → | WEE1 | 28396830 | SIGNOR-279027 |
| CHEK1 | phosphorylation up-regulates → | RHOB PThr175 | phosphorylation up-regulates → | RHOB | 30297842 | SIGNOR-279728 |
| CHEK1 | phosphorylation up-regulates → | PPP1R12A PSer20 | phosphorylation down-regulates ⊣ | PPP1R12A | 29262732 | SIGNOR-277870 |
| CHEK1 | phosphorylation up-regulates → | FANCE PSer374 | phosphorylation up-regulates → | FANCE | 17296736 | SIGNOR-153023 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PThr539 | phosphorylation down-regulates ⊣ | PLK1 | 37596441 | SIGNOR-277914 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217799 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer378 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217857 |
| CHEK1 | phosphorylation up-regulates → | NEK11 PSer273 | phosphorylation up-regulates → | NEK11 | 19734889 | SIGNOR-187863 |
| CHEK1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation down-regulates ⊣ | CDKN1A | 25486478 | SIGNOR-279325 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer76 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163150 |
| CHEK1 | phosphorylation up-regulates → | E2F3 PSer124 | phosphorylation up-regulates → | E2F3 | 19917728 | SIGNOR-161758 |
| CHEK1 | phosphorylation up-regulates → | ERRFI1 PSer251 | phosphorylation down-regulates ⊣ | ERRFI1 | 22505024 | SIGNOR-276411 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PThr507 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163154 |
| CHEK1 | phosphorylation up-regulates → | PABIR1 PSer37 | phosphorylation down-regulates ⊣ | PABIR1 | 33108758 | SIGNOR-266380 |
| CHEK1 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 20068082 | SIGNOR-163158 |
| CHEK1 | phosphorylation up-regulates → | ASF1A PSer166 | phosphorylation up-regulates → | ASF1A | 33503415 | SIGNOR-277620 |
| CHEK1 | phosphorylation up-regulates → | CHEK1 PSer296 | phosphorylation up-regulates → | CHEK1 | 23068608 | SIGNOR-217904 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer124 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163134 |
| CHEK1 | phosphorylation up-regulates → | E2F6 PSer52 | phosphorylation down-regulates ⊣ | E2F6 | 23954429 | SIGNOR-266371 |
| CHEK1 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation up-regulates → | PLK1 | 34197606 | SIGNOR-279501 |
| CHEK1 | phosphorylation up-regulates → | TLK2 PSer750 | phosphorylation down-regulates ⊣ | TLK2 | 12955071 | SIGNOR-262740 |
| CHEK1 | phosphorylation up-regulates → | NFKB1 PSer328 | phosphorylation down-regulates ⊣ | NFKB1 | 22152481 | SIGNOR-195208 |
| CHEK1 | phosphorylation up-regulates → | BLM PThr182 | phosphorylation down-regulates ⊣ | BLM | 26028025 | SIGNOR-276909 |
| CHEK1 | phosphorylation up-regulates → | SETMAR PSer508 | phosphorylation down-regulates ⊣ | SETMAR | 25024738 | SIGNOR-273610 |
| CHEK1 | phosphorylation up-regulates → | RAD51 PThr309 | phosphorylation up-regulates → | RAD51 | 15665856 | SIGNOR-133375 |
| CHEK1 | phosphorylation up-regulates → | CDC25B PSer230 | phosphorylation down-regulates ⊣ | CDC25B | 17003105 | SIGNOR-149898 |
| CHEK1 | phosphorylation up-regulates → | FANCD2 PSer331 | phosphorylation up-regulates → | FANCD2 | 19861535 | SIGNOR-107042 |
| CHEK1 | phosphorylation up-regulates → | TLK1 PSer743 | phosphorylation down-regulates ⊣ | TLK1 | 12660173 | SIGNOR-99653 |
| CHEK1 | phosphorylation up-regulates → | FANCD2 PSer331 | phosphorylation up-regulates → | FANCD2 | 19861535 | SIGNOR-263252 |
| CHEK1 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 18356162 | SIGNOR-178067 |
| CHEK1 | phosphorylation up-regulates → | E2F6 PSer12 | phosphorylation down-regulates ⊣ | E2F6 | 23954429 | SIGNOR-266370 |
| CHEK1 | phosphorylation up-regulates → | CHEK1 PSer296 | phosphorylation up-regulates → | CHEK1 | 15707391 | SIGNOR-219240 |
| CHEK1 | phosphorylation up-regulates → | RB1 PSer612 | phosphorylation up-regulates → | RB1 | 17380128 | SIGNOR-153904 |
| CHEK1 | phosphorylation up-regulates → | TP53 PThr387 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217861 |
| CHEK1 | phosphorylation up-regulates → | H3-3A PThr12 | phosphorylation down-regulates ⊣ | H3-3A | 18243098 | SIGNOR-160557 |
| CHEK1 | phosphorylation up-regulates → | TP73 PSer47 | phosphorylation up-regulates → | TP73 | 14585975 | SIGNOR-118913 |
| CHEK1 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 15659650 | SIGNOR-217795 |
| CHEK1 | phosphorylation up-regulates → | AURKB PSer331 | phosphorylation up-regulates → | AURKB | 17276342 | SIGNOR-152926 |
| CHEK1 | phosphorylation up-regulates → | CDC25A PSer293 | phosphorylation down-regulates ⊣ | CDC25A | 20068082 | SIGNOR-163146 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates | WEE1 | SIGNOR-163164 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217853 |
| CHEK1 | phosphorylation → up-regulates activity | BUB1B | SIGNOR-280223 |
| CHEK1 | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-280224 |
| CHEK1 | phosphorylation → up-regulates activity | RELA | SIGNOR-280225 |
| CHEK1 | phosphorylation → up-regulates activity | TRIM28 | SIGNOR-280226 |
| CHEK1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-277913 |
| CHEK1 | phosphorylation → unknown | SNCB | SIGNOR-174590 |
| CHEK1 | phosphorylation → up-regulates | FANCE | SIGNOR-153027 |
| CHEK1 | phosphorylation → down-regulates activity | DIAPH1 | SIGNOR-279026 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163142 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217791 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163138 |
| CHEK1 | phosphorylation → up-regulates activity | RAD9A | SIGNOR-279503 |
| CHEK1 | phosphorylation down-regulates | SYK | SIGNOR-197528 |
| CHEK1 | phosphorylation → up-regulates activity | RHOB | SIGNOR-279727 |
| CHEK1 | phosphorylation → down-regulates activity | MDM4 | SIGNOR-250770 |
| CHEK1 | phosphorylation → down-regulates activity | BAD | SIGNOR-279159 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-279324 |
| CHEK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279502 |
| CHEK1 | phosphorylation → up-regulates | BLM | SIGNOR-167534 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217803 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | MAP4 | SIGNOR-277846 |
| CHEK1 | phosphorylation → up-regulates activity | SRC | SIGNOR-278332 |
| CHEK1 | phosphorylation → up-regulates | CLSPN | SIGNOR-149411 |
| CHEK1 | phosphorylation → unknown | RASSF1 | SIGNOR-203144 |
| CHEK1 | phosphorylation → up-regulates activity | WEE1 | SIGNOR-279027 |
| CHEK1 | phosphorylation → down-regulates activity | E2F7 | SIGNOR-279692 |
| CHEK1 | phosphorylation → up-regulates activity | RHOB | SIGNOR-279728 |
| CHEK1 | phosphorylation → up-regulates | CDC7 | SIGNOR-163161 |
| CHEK1 | phosphorylation → down-regulates activity | CDH1 | SIGNOR-278396 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | PPP1R12A | SIGNOR-277870 |
| CHEK1 | phosphorylation → up-regulates | FANCE | SIGNOR-153023 |
| CHEK1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-277914 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217799 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217857 |
| CHEK1 | phosphorylation → up-regulates | NEK11 | SIGNOR-187863 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDKN1A | SIGNOR-279325 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163150 |
| CHEK1 | phosphorylation → up-regulates | E2F3 | SIGNOR-161758 |
| CHEK1 | phosphorylation → down-regulates activity | ERRFI1 | SIGNOR-276411 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163154 |
| CHEK1 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265326 |
| CHEK1 | phosphorylation → down-regulates activity | TICRR | SIGNOR-278924 |
| CHEK1 | phosphorylation → down-regulates activity | PABIR1 | SIGNOR-266380 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | CDC25C | SIGNOR-163158 |
| CHEK1 | phosphorylation → up-regulates activity | ASF1A | SIGNOR-277620 |
| CHEK1 | phosphorylation → up-regulates activity | CHEK1 | SIGNOR-217904 |
| CHEK1 | phosphorylation → down-regulates activity | E2F8 | SIGNOR-279693 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163134 |
| CHEK1 | phosphorylation → down-regulates activity | E2F6 | SIGNOR-266371 |
| CHEK1 | phosphorylation → up-regulates activity | PLK1 | SIGNOR-279501 |
| CHEK1 | phosphorylation → down-regulates activity | TLK2 | SIGNOR-262740 |
| CHEK1 | phosphorylation down-regulates | NFKB1 | SIGNOR-195208 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | BLM | SIGNOR-276909 |
| CHEK1 | phosphorylation → down-regulates activity | SETMAR | SIGNOR-273610 |
| CHEK1 | phosphorylation → up-regulates | RAD51 | SIGNOR-133375 |
| CHEK1 | phosphorylation → down-regulates activity | CDC25B | SIGNOR-149898 |
| CHEK1 | phosphorylation → up-regulates activity | FANCD2 | SIGNOR-107042 |
| CHEK1 | phosphorylation down-regulates | TLK1 | SIGNOR-99653 |
| CHEK1 | phosphorylation → up-regulates activity | FANCD2 | SIGNOR-263252 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-178067 |
| CHEK1 | phosphorylation → down-regulates activity | E2F6 | SIGNOR-266370 |
| CHEK1 | phosphorylation → up-regulates activity | CHEK1 | SIGNOR-219240 |
| CHEK1 | phosphorylation → up-regulates activity | RB1 | SIGNOR-153904 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217861 |
| CHEK1 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-160557 |
| CHEK1 | phosphorylation → up-regulates | TP73 | SIGNOR-118913 |
| CHEK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-217795 |
| CHEK1 | phosphorylation → down-regulates activity | NEK6 | SIGNOR-279403 |
| CHEK1 | phosphorylation → up-regulates | AURKB | SIGNOR-152926 |
| CHEK1 | phosphorylation down-regulates | CDC25A | SIGNOR-163146 |