| Name | CHEK1 |
| ID | O14757 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 9-265 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK7 | CHEK1 | – | phosphorylation up-regulates activity | 30804322 | SIGNOR-280028 | |
| ATM | CHEK1 | Ser345 | LVQGISFsQPTCPDH | phosphorylation up-regulates | 20068082 | SIGNOR-163110 |
| PPM1F | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 31944151 | SIGNOR-276987 |
| CDK1 | CHEK1 | Ser286 | TSGGVSEsPSGFSKH | phosphorylation up-regulates | 21765472 | SIGNOR-175071 |
| PPP2CB | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248578 |
| PPP2CA | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248615 |
| PPP2CB | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248579 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276986 |
| CDK1 | CHEK1 | Ser301 | IQSNLDFsPVNSASS | phosphorylation up-regulates | 21765472 | SIGNOR-175075 |
| AKT | CHEK1 | Ser280 | AKRPRVTsGGVSESP | phosphorylation down-regulates | 15107605 | SIGNOR-244206 |
| ATM | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | phosphorylation up-regulates | 20068082 | SIGNOR-163106 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 15870257 | SIGNOR-248317 |
| PPM1F | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 31944151 | SIGNOR-276988 |
| AKT1 | CHEK1 | Ser280 | AKRPRVTsGGVSESP | phosphorylation down-regulates | 15107605 | SIGNOR-124365 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates | 15870257 | SIGNOR-135972 |
| ATR | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | phosphorylation up-regulates | 15775976 | SIGNOR-134712 |
| CDK2 | CHEK1 | Ser301 | IQSNLDFsPVNSASS | phosphorylation up-regulates | 21765472 | SIGNOR-175083 |
| CHEK1 | CHEK1 | Ser296 | GFSKHIQsNLDFSPV | phosphorylation up-regulates activity | 23068608 | SIGNOR-217904 |
| CDK2 | CHEK1 | Ser286 | TSGGVSEsPSGFSKH | phosphorylation up-regulates | 21765472 | SIGNOR-175079 |
| ATR | CHEK1 | Ser345 | LVQGISFsQPTCPDH | phosphorylation up-regulates | 15775976 | SIGNOR-134716 |
| CHEK1 | CHEK1 | Ser296 | GFSKHIQsNLDFSPV | phosphorylation up-regulates activity | 15707391 | SIGNOR-219240 |
| PPP2CA | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248616 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | CHEK1 PSer345 | phosphorylation up-regulates → | CHEK1 | 20068082 | SIGNOR-163110 |
| PPM1F | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 31944151 | SIGNOR-276987 |
| CDK1 | phosphorylation up-regulates → | CHEK1 PSer286 | phosphorylation up-regulates → | CHEK1 | 21765472 | SIGNOR-175071 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248578 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248615 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248579 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 18265945 | SIGNOR-276986 |
| CDK1 | phosphorylation up-regulates → | CHEK1 PSer301 | phosphorylation up-regulates → | CHEK1 | 21765472 | SIGNOR-175075 |
| AKT | phosphorylation up-regulates → | CHEK1 PSer280 | phosphorylation down-regulates ⊣ | CHEK1 | 15107605 | SIGNOR-244206 |
| ATM | phosphorylation up-regulates → | CHEK1 PSer317 | phosphorylation up-regulates → | CHEK1 | 20068082 | SIGNOR-163106 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 15870257 | SIGNOR-248317 |
| PPM1F | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 31944151 | SIGNOR-276988 |
| AKT1 | phosphorylation up-regulates → | CHEK1 PSer280 | phosphorylation down-regulates ⊣ | CHEK1 | 15107605 | SIGNOR-124365 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 15870257 | SIGNOR-135972 |
| ATR | phosphorylation up-regulates → | CHEK1 PSer317 | phosphorylation up-regulates → | CHEK1 | 15775976 | SIGNOR-134712 |
| CDK2 | phosphorylation up-regulates → | CHEK1 PSer301 | phosphorylation up-regulates → | CHEK1 | 21765472 | SIGNOR-175083 |
| CHEK1 | phosphorylation up-regulates → | CHEK1 PSer296 | phosphorylation up-regulates → | CHEK1 | 23068608 | SIGNOR-217904 |
| CDK2 | phosphorylation up-regulates → | CHEK1 PSer286 | phosphorylation up-regulates → | CHEK1 | 21765472 | SIGNOR-175079 |
| ATR | phosphorylation up-regulates → | CHEK1 PSer345 | phosphorylation up-regulates → | CHEK1 | 15775976 | SIGNOR-134716 |
| CHEK1 | phosphorylation up-regulates → | CHEK1 PSer296 | phosphorylation up-regulates → | CHEK1 | 15707391 | SIGNOR-219240 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248616 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK7 | phosphorylation → up-regulates activity | CHEK1 | SIGNOR-280028 |
| ATM | phosphorylation → up-regulates | CHEK1 | SIGNOR-163110 |
| PPM1F | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276987 |
| CDK1 | phosphorylation → up-regulates | CHEK1 | SIGNOR-175071 |
| PPP2CB | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248578 |
| PPP2CA | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248615 |
| PPP2CB | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248579 |
| PPM1D | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276986 |
| CDK1 | phosphorylation → up-regulates | CHEK1 | SIGNOR-175075 |
| AKT | phosphorylation down-regulates | CHEK1 | SIGNOR-244206 |
| ATM | phosphorylation → up-regulates | CHEK1 | SIGNOR-163106 |
| PPM1D | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248317 |
| PPM1F | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276988 |
| AKT1 | phosphorylation down-regulates | CHEK1 | SIGNOR-124365 |
| PPM1D | dephosphorylation down-regulates | CHEK1 | SIGNOR-135972 |
| ATR | phosphorylation → up-regulates | CHEK1 | SIGNOR-134712 |
| CDK2 | phosphorylation → up-regulates | CHEK1 | SIGNOR-175083 |
| CHEK1 | phosphorylation → up-regulates activity | CHEK1 | SIGNOR-217904 |
| CDK2 | phosphorylation → up-regulates | CHEK1 | SIGNOR-175079 |
| ATR | phosphorylation → up-regulates | CHEK1 | SIGNOR-134716 |
| CHEK1 | phosphorylation → up-regulates activity | CHEK1 | SIGNOR-219240 |
| PPP2CA | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248616 |