| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | phosphorylation up-regulates | 15775976 | SIGNOR-134712 |
| PPP2CA | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248616 |
| PPM1F | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 31944151 | SIGNOR-276987 |
| PPP2CB | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248579 |
| ATM | CHEK1 | Ser317 | ENVKYSSsQPEPRTG | phosphorylation up-regulates | 20068082 | SIGNOR-163106 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | CHEK1 PSer317 | phosphorylation up-regulates → | CHEK1 | 15775976 | SIGNOR-134712 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248616 |
| PPM1F | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 31944151 | SIGNOR-276987 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK1 PSer317 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248579 |
| ATM | phosphorylation up-regulates → | CHEK1 PSer317 | phosphorylation up-regulates → | CHEK1 | 20068082 | SIGNOR-163106 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → up-regulates | CHEK1 | SIGNOR-134712 |
| PPP2CA | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248616 |
| PPM1F | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276987 |
| PPP2CB | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248579 |
| ATM | phosphorylation → up-regulates | CHEK1 | SIGNOR-163106 |
