| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 15870257 | SIGNOR-248317 |
| PPM1F | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 31944151 | SIGNOR-276988 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates | 15870257 | SIGNOR-135972 |
| ATR | CHEK1 | Ser345 | LVQGISFsQPTCPDH | phosphorylation up-regulates | 15775976 | SIGNOR-134716 |
| ATM | CHEK1 | Ser345 | LVQGISFsQPTCPDH | phosphorylation up-regulates | 20068082 | SIGNOR-163110 |
| PPP2CB | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248578 |
| PPP2CA | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 17015476 | SIGNOR-248615 |
| PPM1D | CHEK1 | Ser345 | LVQGISFsQPTCPDH | dephosphorylation down-regulates activity | 18265945 | SIGNOR-276986 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 15870257 | SIGNOR-248317 |
| PPM1F | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 31944151 | SIGNOR-276988 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 15870257 | SIGNOR-135972 |
| ATR | phosphorylation up-regulates → | CHEK1 PSer345 | phosphorylation up-regulates → | CHEK1 | 15775976 | SIGNOR-134716 |
| ATM | phosphorylation up-regulates → | CHEK1 PSer345 | phosphorylation up-regulates → | CHEK1 | 20068082 | SIGNOR-163110 |
| PPP2CB | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248578 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 17015476 | SIGNOR-248615 |
| PPM1D | dephosphorylation down-regulates ⊣ | CHEK1 PSer345 | dephosphorylation up-regulates → | CHEK1 | 18265945 | SIGNOR-276986 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248317 |
| PPM1F | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276988 |
| PPM1D | dephosphorylation down-regulates | CHEK1 | SIGNOR-135972 |
| ATR | phosphorylation → up-regulates | CHEK1 | SIGNOR-134716 |
| ATM | phosphorylation → up-regulates | CHEK1 | SIGNOR-163110 |
| PPP2CB | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248578 |
| PPP2CA | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-248615 |
| PPM1D | dephosphorylation → down-regulates activity | CHEK1 | SIGNOR-276986 |
