| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | NDC80 | Ser5 | sVSSGGAG | phosphorylation down-regulates | 20471944 | SIGNOR-165562 |
| AURKB | NDC80 | Ser15 | SGGAGRLsMQELRSQ | phosphorylation down-regulates | 20471944 | SIGNOR-165554 |
| AURKB | NDC80 | Ser44 | KPTFGKLsINKPTSE | phosphorylation down-regulates | 20471944 | SIGNOR-165558 |
| NEK2 | NDC80 | Ser165 | LGYPFALsKSSMYTV | phosphorylation up-regulates | 12386167 | SIGNOR-94322 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | NDC80 PSer5 | phosphorylation down-regulates ⊣ | NDC80 | 20471944 | SIGNOR-165562 |
| AURKB | phosphorylation up-regulates → | NDC80 PSer15 | phosphorylation down-regulates ⊣ | NDC80 | 20471944 | SIGNOR-165554 |
| AURKB | phosphorylation up-regulates → | NDC80 PSer44 | phosphorylation down-regulates ⊣ | NDC80 | 20471944 | SIGNOR-165558 |
| NEK2 | phosphorylation up-regulates → | NDC80 PSer165 | phosphorylation up-regulates → | NDC80 | 12386167 | SIGNOR-94322 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation down-regulates | NDC80 | SIGNOR-165562 |
| AURKB | phosphorylation down-regulates | NDC80 | SIGNOR-165554 |
| AURKB | phosphorylation down-regulates | NDC80 | SIGNOR-165558 |
| NEK2 | phosphorylation → up-regulates | NDC80 | SIGNOR-94322 |
