| Name | IKBKB |
| ID | O14920 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 15-300 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | IKBKG | Ser68 | LRDAIRQsNQILRER | phosphorylation down-regulates activity | 17977820 | SIGNOR-158659 |
| IKBKB | BCL10 | Ser136 | ATNNLSRsNSDESNF | phosphorylation up-regulates activity | 16818229 | SIGNOR-276290 |
| IKBKB | IRS1 | Ser312 | TESITATsPASMVGG | phosphorylation down-regulates activity | 12351658 | SIGNOR-251293 |
| IKBKB | IKBKB | Ser740 | SFTALDWsWLQTEEE | phosphorylation down-regulates activity | 10195894 | SIGNOR-236048 |
| IKBKB | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 19188143 | SIGNOR-183684 |
| IKBKB | IKBKB | Ser675 | PVSGSPDsMNASRLS | phosphorylation down-regulates activity | 10195894 | SIGNOR-251276 |
| IKBKB | DOK1 | Ser439 | EPGTATGsGIKSHNS | phosphorylation up-regulates | 15574499 | SIGNOR-131447 |
| IKBKB | IRS1 | Ser270 | EFRPRSKsQSSSNCS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251289 |
| IKBKB | IRS1 | Ser527 | RFRKRTHsAGTSPTI | phosphorylation down-regulates activity | 12351658 | SIGNOR-251296 |
| IKBKB | BCL2L1 | – | phosphorylation down-regulates quantity | 19488402 | SIGNOR-279529 | |
| IKBKB | COPS5 | Thr205 | EGPSEYQtIPLNKIE | phosphorylation down-regulates activity | 31950832 | SIGNOR-275519 |
| IKBKB | NfKb-p65/p50 | – | phosphorylation down-regulates | 10469655 | SIGNOR-217400 | |
| IKBKB | NFKBIB | – | phosphorylation down-regulates | 9346241 | SIGNOR-52932 | |
| IKBKB | IKBKB | Ser756 | HSCLEQAs | phosphorylation down-regulates activity | 10195894 | SIGNOR-251284 |
| IKBKB | FOXO | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 19188143 | SIGNOR-252947 |
| IKBKB | IKBKB | Ser697 | QPSTASNsLPEPAKK | phosphorylation down-regulates activity | 10195894 | SIGNOR-251282 |
| IKBKB | GLI1 | – | phosphorylation up-regulates activity | 26603838 | SIGNOR-279194 | |
| IKBKB | DOK1 | Ser443 | ATGSGIKsHNSALYS | phosphorylation up-regulates | 15574499 | SIGNOR-131451 |
| IKBKB | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-249365 |
| IKBKB | IRS1 | Ser268 | SDEFRPRsKSQSSSN | phosphorylation down-regulates activity | 12351658 | SIGNOR-251288 |
| IKBKB | NCOA3 | – | phosphorylation up-regulates activity | 11971985 | SIGNOR-251298 | |
| IKBKB | DOK1 | Ser450 | SHNSALYsQVQKSGA | phosphorylation up-regulates | 15574499 | SIGNOR-131556 |
| IKBKB | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates activity | 11158290 | SIGNOR-104811 |
| IKBKB | IKBKB | Ser733 | TVREQDQsFTALDWS | phosphorylation down-regulates activity | 10195894 | SIGNOR-66344 |
| IKBKB | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 24614225 | SIGNOR-204716 |
| IKBKB | IKBKB | Ser672 | VRGPVSGsPDSMNAS | phosphorylation down-regulates activity | 10195894 | SIGNOR-251275 |
| IKBKB | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates activity | 11158290 | SIGNOR-104803 |
| IKBKB | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70469 |
| IKBKB | IRF5 | Ser446 | DSIRLQIsNPDLKDR | phosphorylation up-regulates activity | 25326420 | SIGNOR-279466 |
| IKBKB | CYLD | Ser444 | PLSLSAQsVMEELNT | phosphorylation down-regulates activity | 24614225 | SIGNOR-204740 |
| IKBKB | TSC1 | Ser511 | DSPFYRDsLPGSQRK | phosphorylation down-regulates | 19188143 | SIGNOR-183692 |
| IKBKB | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 11815618 | SIGNOR-249366 |
| IKBKB | BCL10 | Ser134 | DGATNNLsRSNSDES | phosphorylation up-regulates activity | 16818229 | SIGNOR-276291 |
| IKBKB | BCL3 | Ser122 | CPMEHPLsADIAMAT | phosphorylation up-regulates activity | 28689659 | SIGNOR-277364 |
| IKBKB | BCL3 | Ser454 | PSPAPGGs | phosphorylation up-regulates activity | 28689659 | SIGNOR-277365 |
| IKBKB | CYLD | Ser436 | TNGSIGHsPLSLSAQ | phosphorylation down-regulates activity | 24614225 | SIGNOR-204728 |
| IKBKB | IKBKG | Ser31 | QDVLGEEsPLGKPAM | phosphorylation unknown | 12657630 | SIGNOR-251285 |
| IKBKB | REL | – | phosphorylation up-regulates activity | 19110719 | SIGNOR-279620 | |
| IKBKB | CYLD | Ser441 | GHSPLSLsAQSVMEE | phosphorylation up-regulates activity | 24614225 | SIGNOR-204736 |
| IKBKB | IKBKB | Ser682 | SMNASRLsQPGQLMS | phosphorylation down-regulates activity | 10195894 | SIGNOR-251278 |
| IKBKB | TARDBP | Thr8 | MSEYIRVtEDENDEP | phosphorylation down-regulates quantity by destabilization | 38197897 | SIGNOR-277861 |
| IKBKB | IRS1 | Ser341 | GTMSRPAsVDGSPVS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251294 |
| IKBKB | COPS5 | Ser201 | KPPDEGPsEYQTIPL | phosphorylation down-regulates activity | 31950832 | SIGNOR-275518 |
| IKBKB | IRS1 | Ser272 | RPRSKSQsSSNCSNP | phosphorylation down-regulates activity | 12351658 | SIGNOR-251290 |
| IKBKB | TMIGD2 | Ser220 | GKDQRGQsIYSTSFP | phosphorylation up-regulates activity | 32978258 | SIGNOR-273642 |
| IKBKB | BCL10 | Ser141 | SRSNSDEsNFSEKLR | phosphorylation up-regulates activity | 16818229 | SIGNOR-276293 |
| IKBKB | PFKFB3 | Ser269 | QGRIGGDsGLSSRGK | phosphorylation down-regulates activity | 27585591 | SIGNOR-277278 |
| IKBKB | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129935 |
| IKBKB | TRIM23 | – | phosphorylation down-regulates activity | 19716809 | SIGNOR-279337 | |
| IKBKB | IKBKG | Ser376 | PPAPAYLsSPLALPS | phosphorylation unknown | 12657630 | SIGNOR-251286 |
| IKBKB | CYLD | Ser422 | RFHSLPFsLTKMPNT | phosphorylation up-regulates activity | 24614225 | SIGNOR-204720 |
| IKBKB | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 30478303 | SIGNOR-278516 |
| IKBKB | TWIST1 | Ser123 | RERQRTQsLNEAFAA | phosphorylation down-regulates activity | 23375009 | SIGNOR-278405 |
| IKBKB | RAPGEF2 | – | phosphorylation down-regulates quantity by destabilization | 24290981 | SIGNOR-279805 | |
| IKBKB | TSC1 | Ser487 | AAISRELsEITTAEA | phosphorylation down-regulates | 17693255 | SIGNOR-157296 |
| IKBKB | CYLD | Ser432 | KMPNTNGsIGHSPLS | phosphorylation down-regulates activity | 24614225 | SIGNOR-204724 |
| IKBKB | RAPGEF2 | – | phosphorylation down-regulates quantity by destabilization | 24290981 | SIGNOR-279807 | |
| IKBKB | DOK1 | Ser446 | SGIKSHNsALYSQVQ | phosphorylation up-regulates | 15574499 | SIGNOR-131455 |
| IKBKB | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70473 |
| IKBKB | RPS3 | Ser209 | KPLPDHVsIVEPKDE | phosphorylation up-regulates activity | 21399639 | SIGNOR-278360 |
| IKBKB | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation unknown | 12657630 | SIGNOR-251287 |
| IKBKB | BAD | – | phosphorylation down-regulates | 23332762 | SIGNOR-192614 | |
| IKBKB | RELA | Ser468 | AVFTDLAsVDNSEFQ | phosphorylation up-regulates activity | 16046471 | SIGNOR-138903 |
| IKBKB | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 15870263 | SIGNOR-266436 |
| IKBKB | BCL10 | Ser138 | NNLSRSNsDESNFSE | phosphorylation up-regulates activity | 16818229 | SIGNOR-276292 |
| IKBKB | TSC1 | Ser487 | AAISRELsEITTAEA | phosphorylation down-regulates | 19188143 | SIGNOR-183688 |
| IKBKB | TWIST1 | Thr121 | NVRERQRtQSLNEAF | phosphorylation down-regulates activity | 23375009 | SIGNOR-278404 |
| IKBKB | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation unknown | 17977820 | SIGNOR-158655 |
| IKBKB | ASB8 | Ser31 | RTIAAIRsFPHDNVE | phosphorylation up-regulates activity | 31009856 | SIGNOR-272242 |
| IKBKB | IKBKB | Ser705 | LPEPAKKsEELVAEA | phosphorylation down-regulates activity | 10195894 | SIGNOR-251283 |
| IKBKB | IKBKB | Ser670 | SKVRGPVsGSPDSMN | phosphorylation down-regulates activity | 10195894 | SIGNOR-251274 |
| IKBKB | CYLD | Ser439 | SIGHSPLsLSAQSVM | phosphorylation down-regulates activity | 24614225 | SIGNOR-204732 |
| IKBKB | YWHAB | Ser132 | GDYFRYLsEVASGDN | phosphorylation down-regulates | 16024783 | SIGNOR-138608 |
| IKBKB | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-124207 |
| IKBKB | IRS1 | Ser345 | RPASVDGsPVSPSTN | phosphorylation down-regulates activity | 12351658 | SIGNOR-251295 |
| IKBKB | CDKN2A | Ser8 | MEPAAGSsMEPSADW | phosphorylation down-regulates | 20152798 | SIGNOR-163801 |
| IKBKB | IKBKB | Ser679 | SPDSMNAsRLSQPGQ | phosphorylation down-regulates activity | 10195894 | SIGNOR-251277 |
| IKBKB | BCL10 | Ser144 | NSDESNFsEKLRAST | phosphorylation up-regulates activity | 16818229 | SIGNOR-276289 |
| IKBKB | NfKb-p65/p50 | – | phosphorylation unknown | 15489227 | SIGNOR-217376 | |
| IKBKB | TARDBP | Ser92 | MDETDASsAVKVKRA | phosphorylation down-regulates quantity by destabilization | 38197897 | SIGNOR-277860 |
| IKBKB | IKBKG | Ser85 | ELLHFQAsQREEKEF | phosphorylation down-regulates activity | 17977820 | SIGNOR-158663 |
| IKBKB | FOXO | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-252948 |
| IKBKB | IKBKB | Ser689 | SQPGQLMsQPSTASN | phosphorylation down-regulates activity | 10195894 | SIGNOR-251279 |
| IKBKB | NfKb-p65/p50 | – | phosphorylation unknown | 16046471 | SIGNOR-217427 | |
| IKBKB | NFKBIA | – | phosphorylation down-regulates activity | 21232017 | SIGNOR-235400 | |
| IKBKB | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70465 |
| IKBKB | TSC1 | Ser511 | DSPFYRDsLPGSQRK | phosphorylation down-regulates | 17693255 | SIGNOR-157300 |
| IKBKB | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates activity | 11158290 | SIGNOR-104807 |
| IKBKB | IKBKB | Ser750 | QTEEEEHsCLEQAS | phosphorylation down-regulates activity | 10195894 | SIGNOR-66352 |
| IKBKB | IRS1 | Ser531 | RTHSAGTsPTITHQK | phosphorylation down-regulates activity | 12351658 | SIGNOR-251297 |
| IKBKB | IKBKB | Ser695 | MSQPSTAsNSLPEPA | phosphorylation down-regulates activity | 10195894 | SIGNOR-251281 |
| IKBKB | IKBKB | Ser692 | GQLMSQPsTASNSLP | phosphorylation down-regulates activity | 10195894 | SIGNOR-251280 |
| IKBKB | RBFOX2 | – | phosphorylation up-regulates activity | 20686657 | SIGNOR-279336 | |
| IKBKB | NfKb-p65/p50 | – | phosphorylation down-regulates | 11158290 | SIGNOR-217403 | |
| IKBKB | IRS1 | Ser307 | TRRSRTEsITATSPA | phosphorylation down-regulates activity | 12351658 | SIGNOR-251292 |
| IKBKB | IRS1 | Ser274 | RSKSQSSsNCSNPIS | phosphorylation down-regulates activity | 12351658 | SIGNOR-251291 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | IKBKG PSer68 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-158659 |
| IKBKB | phosphorylation up-regulates → | BCL10 PSer136 | phosphorylation up-regulates → | BCL10 | 16818229 | SIGNOR-276290 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer312 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251293 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer740 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-236048 |
| IKBKB | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-183684 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer675 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251276 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer439 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131447 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer270 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251289 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer527 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251296 |
| IKBKB | phosphorylation up-regulates → | COPS5 PThr205 | phosphorylation down-regulates ⊣ | COPS5 | 31950832 | SIGNOR-275519 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer756 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251284 |
| IKBKB | phosphorylation up-regulates → | FOXO PSer644 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252947 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer697 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251282 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer443 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131451 |
| IKBKB | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-249365 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer268 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251288 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer450 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131556 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104811 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer733 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-66344 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204716 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer672 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251275 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104803 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70469 |
| IKBKB | phosphorylation up-regulates → | IRF5 PSer446 | phosphorylation up-regulates → | IRF5 | 25326420 | SIGNOR-279466 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer444 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204740 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer511 | phosphorylation down-regulates ⊣ | TSC1 | 19188143 | SIGNOR-183692 |
| IKBKB | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 11815618 | SIGNOR-249366 |
| IKBKB | phosphorylation up-regulates → | BCL10 PSer134 | phosphorylation up-regulates → | BCL10 | 16818229 | SIGNOR-276291 |
| IKBKB | phosphorylation up-regulates → | BCL3 PSer122 | phosphorylation up-regulates → | BCL3 | 28689659 | SIGNOR-277364 |
| IKBKB | phosphorylation up-regulates → | BCL3 PSer454 | phosphorylation up-regulates → | BCL3 | 28689659 | SIGNOR-277365 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer436 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204728 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer31 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-251285 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer441 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204736 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer682 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251278 |
| IKBKB | phosphorylation up-regulates → | TARDBP PThr8 | phosphorylation down-regulates ⊣ | TARDBP | 38197897 | SIGNOR-277861 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer341 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251294 |
| IKBKB | phosphorylation up-regulates → | COPS5 PSer201 | phosphorylation down-regulates ⊣ | COPS5 | 31950832 | SIGNOR-275518 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer272 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251290 |
| IKBKB | phosphorylation up-regulates → | TMIGD2 PSer220 | phosphorylation up-regulates → | TMIGD2 | 32978258 | SIGNOR-273642 |
| IKBKB | phosphorylation up-regulates → | BCL10 PSer141 | phosphorylation up-regulates → | BCL10 | 16818229 | SIGNOR-276293 |
| IKBKB | phosphorylation up-regulates → | PFKFB3 PSer269 | phosphorylation down-regulates ⊣ | PFKFB3 | 27585591 | SIGNOR-277278 |
| IKBKB | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129935 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer376 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-251286 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer422 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204720 |
| IKBKB | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 30478303 | SIGNOR-278516 |
| IKBKB | phosphorylation up-regulates → | TWIST1 PSer123 | phosphorylation down-regulates ⊣ | TWIST1 | 23375009 | SIGNOR-278405 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer487 | phosphorylation down-regulates ⊣ | TSC1 | 17693255 | SIGNOR-157296 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer432 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204724 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer446 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131455 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70473 |
| IKBKB | phosphorylation up-regulates → | RPS3 PSer209 | phosphorylation up-regulates → | RPS3 | 21399639 | SIGNOR-278360 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-251287 |
| IKBKB | phosphorylation up-regulates → | RELA PSer468 | phosphorylation up-regulates → | RELA | 16046471 | SIGNOR-138903 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 15870263 | SIGNOR-266436 |
| IKBKB | phosphorylation up-regulates → | BCL10 PSer138 | phosphorylation up-regulates → | BCL10 | 16818229 | SIGNOR-276292 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer487 | phosphorylation down-regulates ⊣ | TSC1 | 19188143 | SIGNOR-183688 |
| IKBKB | phosphorylation up-regulates → | TWIST1 PThr121 | phosphorylation down-regulates ⊣ | TWIST1 | 23375009 | SIGNOR-278404 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-158655 |
| IKBKB | phosphorylation up-regulates → | ASB8 PSer31 | phosphorylation up-regulates → | ASB8 | 31009856 | SIGNOR-272242 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer705 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251283 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer670 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251274 |
| IKBKB | phosphorylation up-regulates → | CYLD PSer439 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204732 |
| IKBKB | phosphorylation up-regulates → | YWHAB PSer132 | phosphorylation down-regulates ⊣ | YWHAB | 16024783 | SIGNOR-138608 |
| IKBKB | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-124207 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer345 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251295 |
| IKBKB | phosphorylation up-regulates → | CDKN2A PSer8 | phosphorylation down-regulates ⊣ | CDKN2A | 20152798 | SIGNOR-163801 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer679 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251277 |
| IKBKB | phosphorylation up-regulates → | BCL10 PSer144 | phosphorylation up-regulates → | BCL10 | 16818229 | SIGNOR-276289 |
| IKBKB | phosphorylation up-regulates → | TARDBP PSer92 | phosphorylation down-regulates ⊣ | TARDBP | 38197897 | SIGNOR-277860 |
| IKBKB | phosphorylation up-regulates → | IKBKG PSer85 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-158663 |
| IKBKB | phosphorylation up-regulates → | FOXO PSer644 | phosphorylation down-regulates ⊣ | FOXO | 15084260 | SIGNOR-252948 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer689 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251279 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70465 |
| IKBKB | phosphorylation up-regulates → | TSC1 PSer511 | phosphorylation down-regulates ⊣ | TSC1 | 17693255 | SIGNOR-157300 |
| IKBKB | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 11158290 | SIGNOR-104807 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer750 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-66352 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer531 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251297 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer695 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251281 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer692 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251280 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer307 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251292 |
| IKBKB | phosphorylation up-regulates → | IRS1 PSer274 | phosphorylation down-regulates ⊣ | IRS1 | 12351658 | SIGNOR-251291 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → down-regulates activity | IKBKG | SIGNOR-158659 |
| IKBKB | phosphorylation → up-regulates activity | BCL10 | SIGNOR-276290 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251293 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-236048 |
| IKBKB | phosphorylation down-regulates | FOXO3 | SIGNOR-183684 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251276 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131447 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251289 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251296 |
| IKBKB | phosphorylation → down-regulates quantity | BCL2L1 | SIGNOR-279529 |
| IKBKB | phosphorylation → down-regulates activity | COPS5 | SIGNOR-275519 |
| IKBKB | phosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217400 |
| IKBKB | phosphorylation down-regulates | NFKBIB | SIGNOR-52932 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251284 |
| IKBKB | phosphorylation down-regulates | FOXO | SIGNOR-252947 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251282 |
| IKBKB | phosphorylation → up-regulates activity | GLI1 | SIGNOR-279194 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131451 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249365 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251288 |
| IKBKB | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-251298 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131556 |
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104811 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-66344 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204716 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251275 |
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104803 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70469 |
| IKBKB | phosphorylation → up-regulates activity | IRF5 | SIGNOR-279466 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204740 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-183692 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-249366 |
| IKBKB | phosphorylation → up-regulates activity | BCL10 | SIGNOR-276291 |
| IKBKB | phosphorylation → up-regulates activity | BCL3 | SIGNOR-277364 |
| IKBKB | phosphorylation → up-regulates activity | BCL3 | SIGNOR-277365 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204728 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-251285 |
| IKBKB | phosphorylation → up-regulates activity | REL | SIGNOR-279620 |
| IKBKB | phosphorylation → up-regulates activity | CYLD | SIGNOR-204736 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251278 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | TARDBP | SIGNOR-277861 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251294 |
| IKBKB | phosphorylation → down-regulates activity | COPS5 | SIGNOR-275518 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251290 |
| IKBKB | phosphorylation → up-regulates activity | TMIGD2 | SIGNOR-273642 |
| IKBKB | phosphorylation → up-regulates activity | BCL10 | SIGNOR-276293 |
| IKBKB | phosphorylation → down-regulates activity | PFKFB3 | SIGNOR-277278 |
| IKBKB | phosphorylation → up-regulates activity | RELA | SIGNOR-129935 |
| IKBKB | phosphorylation → down-regulates activity | TRIM23 | SIGNOR-279337 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-251286 |
| IKBKB | phosphorylation → up-regulates activity | CYLD | SIGNOR-204720 |
| IKBKB | phosphorylation → up-regulates activity | TP53 | SIGNOR-278516 |
| IKBKB | phosphorylation → down-regulates activity | TWIST1 | SIGNOR-278405 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | RAPGEF2 | SIGNOR-279805 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-157296 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204724 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | RAPGEF2 | SIGNOR-279807 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131455 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70473 |
| IKBKB | phosphorylation → up-regulates activity | RPS3 | SIGNOR-278360 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-251287 |
| IKBKB | phosphorylation down-regulates | BAD | SIGNOR-192614 |
| IKBKB | phosphorylation → up-regulates activity | RELA | SIGNOR-138903 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-266436 |
| IKBKB | phosphorylation → up-regulates activity | BCL10 | SIGNOR-276292 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-183688 |
| IKBKB | phosphorylation → down-regulates activity | TWIST1 | SIGNOR-278404 |
| IKBKB | phosphorylation → unknown | IKBKG | SIGNOR-158655 |
| IKBKB | phosphorylation → up-regulates activity | ASB8 | SIGNOR-272242 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251283 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251274 |
| IKBKB | phosphorylation → down-regulates activity | CYLD | SIGNOR-204732 |
| IKBKB | phosphorylation down-regulates | YWHAB | SIGNOR-138608 |
| IKBKB | phosphorylation down-regulates | FOXO3 | SIGNOR-124207 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251295 |
| IKBKB | phosphorylation down-regulates | CDKN2A | SIGNOR-163801 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251277 |
| IKBKB | phosphorylation → up-regulates activity | BCL10 | SIGNOR-276289 |
| IKBKB | phosphorylation → unknown | NfKb-p65/p50 | SIGNOR-217376 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | TARDBP | SIGNOR-277860 |
| IKBKB | phosphorylation → down-regulates activity | IKBKG | SIGNOR-158663 |
| IKBKB | phosphorylation down-regulates | FOXO | SIGNOR-252948 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251279 |
| IKBKB | phosphorylation → unknown | NfKb-p65/p50 | SIGNOR-217427 |
| IKBKB | phosphorylation → down-regulates activity | NFKBIA | SIGNOR-235400 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70465 |
| IKBKB | phosphorylation down-regulates | TSC1 | SIGNOR-157300 |
| IKBKB | phosphorylation → down-regulates activity | NFKB1 | SIGNOR-104807 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-66352 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251297 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251281 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251280 |
| IKBKB | phosphorylation → up-regulates activity | RBFOX2 | SIGNOR-279336 |
| IKBKB | phosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217403 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251292 |
| IKBKB | phosphorylation → down-regulates activity | IRS1 | SIGNOR-251291 |