| Name | IKBKB |
| ID | O14920 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 15-300 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K3 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 14636585 | SIGNOR-279468 |
| PRKCE | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 23123196 | SIGNOR-278323 |
| IKBKB | IKBKB | Ser682 | SMNASRLsQPGQLMS | phosphorylation down-regulates activity | 10195894 | SIGNOR-251278 |
| PRKAA2 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates | 21673972 | SIGNOR-174401 |
| PRKCZ | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 10022904 | SIGNOR-249016 |
| PPM1A | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates | 18930133 | SIGNOR-181655 |
| PPM1B | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates | 18930133 | SIGNOR-181663 |
| PLK1 | IKBKB | Ser733 | TVREQDQsFTALDWS | phosphorylation down-regulates | 18957422 | SIGNOR-181798 |
| MAP3K14 | IKBKB | – | phosphorylation up-regulates | 9520446 | SIGNOR-55949 | |
| PRKAA2 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates | 21673972 | SIGNOR-174405 |
| PPM1B | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248343 |
| CHUK | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 10022904 | SIGNOR-250772 |
| MAP3K7 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 11460167 | SIGNOR-109494 |
| IKBKB | IKBKB | Ser705 | LPEPAKKsEELVAEA | phosphorylation down-regulates activity | 10195894 | SIGNOR-251283 |
| IKBKB | IKBKB | Ser670 | SKVRGPVsGSPDSMN | phosphorylation down-regulates activity | 10195894 | SIGNOR-251274 |
| PDPK1 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 16207722 | SIGNOR-279088 |
| MAP3K7 | IKBKB | – | phosphorylation up-regulates activity | 19632174 | SIGNOR-187242 | |
| IKBKB | IKBKB | Ser679 | SPDSMNAsRLSQPGQ | phosphorylation down-regulates activity | 10195894 | SIGNOR-251277 |
| PLK1 | IKBKB | Ser740 | SFTALDWsWLQTEEE | phosphorylation down-regulates | 18957422 | SIGNOR-181802 |
| PPM1A | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248487 |
| IKBKB | IKBKB | Ser689 | SQPGQLMsQPSTASN | phosphorylation down-regulates activity | 10195894 | SIGNOR-251279 |
| IKBKB | IKBKB | Ser750 | QTEEEEHsCLEQAS | phosphorylation down-regulates activity | 10195894 | SIGNOR-66352 |
| IKBKB | IKBKB | Ser695 | MSQPSTAsNSLPEPA | phosphorylation down-regulates activity | 10195894 | SIGNOR-251281 |
| MAP3K7 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 11460167 | SIGNOR-109490 |
| IKBKB | IKBKB | Ser692 | GQLMSQPsTASNSLP | phosphorylation down-regulates activity | 10195894 | SIGNOR-251280 |
| PLK1 | IKBKB | Ser750 | QTEEEEHsCLEQAS | phosphorylation down-regulates | 18957422 | SIGNOR-181806 |
| SRC | IKBKB | Tyr188 | SFVGTLQyLAPELLE | phosphorylation up-regulates activity | 12707358 | SIGNOR-100784 |
| PPM1B | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248344 |
| IKBKB | IKBKB | Ser740 | SFTALDWsWLQTEEE | phosphorylation down-regulates activity | 10195894 | SIGNOR-236048 |
| TBK1 | IKBKB | – | phosphorylation up-regulates activity | 30791439 | SIGNOR-280017 | |
| IKBKB | IKBKB | Ser675 | PVSGSPDsMNASRLS | phosphorylation down-regulates activity | 10195894 | SIGNOR-251276 |
| CHUK | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 10022904 | SIGNOR-250771 |
| MAP3K1 | IKBKB | – | phosphorylation up-regulates activity | 9630230 | SIGNOR-279339 | |
| SRC | IKBKB | Tyr199 | ELLEQQKyTVTVDYW | phosphorylation up-regulates | 12645577 | SIGNOR-99318 |
| PPM1A | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates | 18930133 | SIGNOR-181659 |
| PPM1A | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248486 |
| IKBKB | IKBKB | Ser756 | HSCLEQAs | phosphorylation down-regulates activity | 10195894 | SIGNOR-251284 |
| MAP3K3 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 14636585 | SIGNOR-279467 |
| PRKCZ | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 10022904 | SIGNOR-249015 |
| IKBKB | IKBKB | Ser697 | QPSTASNsLPEPAKK | phosphorylation down-regulates activity | 10195894 | SIGNOR-251282 |
| PPP2CB | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 19607706 | SIGNOR-248581 |
| SRC | IKBKB | Tyr188 | SFVGTLQyLAPELLE | phosphorylation up-regulates | 12645577 | SIGNOR-99314 |
| IKBKB | IKBKB | Ser733 | TVREQDQsFTALDWS | phosphorylation down-regulates activity | 10195894 | SIGNOR-66344 |
| PPP2CB | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 19607706 | SIGNOR-248580 |
| IKBKB | IKBKB | Ser672 | VRGPVSGsPDSMNAS | phosphorylation down-regulates activity | 10195894 | SIGNOR-251275 |
| PPM1B | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates | 18930133 | SIGNOR-181667 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K3 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 14636585 | SIGNOR-279468 |
| PRKCE | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 23123196 | SIGNOR-278323 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer682 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251278 |
| PRKAA2 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 21673972 | SIGNOR-174401 |
| PRKCZ | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-249016 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181655 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181663 |
| PLK1 | phosphorylation up-regulates → | IKBKB PSer733 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181798 |
| PRKAA2 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 21673972 | SIGNOR-174405 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248343 |
| CHUK | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-250772 |
| MAP3K7 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 11460167 | SIGNOR-109494 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer705 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251283 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer670 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251274 |
| PDPK1 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 16207722 | SIGNOR-279088 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer679 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251277 |
| PLK1 | phosphorylation up-regulates → | IKBKB PSer740 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181802 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248487 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer689 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251279 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer750 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-66352 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer695 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251281 |
| MAP3K7 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 11460167 | SIGNOR-109490 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer692 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251280 |
| PLK1 | phosphorylation up-regulates → | IKBKB PSer750 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181806 |
| SRC | phosphorylation up-regulates → | IKBKB PTyr188 | phosphorylation up-regulates → | IKBKB | 12707358 | SIGNOR-100784 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248344 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer740 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-236048 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer675 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251276 |
| CHUK | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-250771 |
| SRC | phosphorylation up-regulates → | IKBKB PTyr199 | phosphorylation up-regulates → | IKBKB | 12645577 | SIGNOR-99318 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181659 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248486 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer756 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251284 |
| MAP3K3 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 14636585 | SIGNOR-279467 |
| PRKCZ | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-249015 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer697 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251282 |
| PPP2CB | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 19607706 | SIGNOR-248581 |
| SRC | phosphorylation up-regulates → | IKBKB PTyr188 | phosphorylation up-regulates → | IKBKB | 12645577 | SIGNOR-99314 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer733 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-66344 |
| PPP2CB | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 19607706 | SIGNOR-248580 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer672 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-251275 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181667 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K3 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279468 |
| PRKCE | phosphorylation → up-regulates activity | IKBKB | SIGNOR-278323 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251278 |
| PRKAA2 | phosphorylation → up-regulates | IKBKB | SIGNOR-174401 |
| PRKCZ | phosphorylation → up-regulates activity | IKBKB | SIGNOR-249016 |
| PPM1A | dephosphorylation down-regulates | IKBKB | SIGNOR-181655 |
| PPM1B | dephosphorylation down-regulates | IKBKB | SIGNOR-181663 |
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181798 |
| MAP3K14 | phosphorylation → up-regulates | IKBKB | SIGNOR-55949 |
| PRKAA2 | phosphorylation → up-regulates | IKBKB | SIGNOR-174405 |
| PPM1B | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248343 |
| CHUK | phosphorylation → up-regulates activity | IKBKB | SIGNOR-250772 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-109494 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251283 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251274 |
| PDPK1 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279088 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-187242 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251277 |
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181802 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248487 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251279 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-66352 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251281 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-109490 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251280 |
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181806 |
| SRC | phosphorylation → up-regulates activity | IKBKB | SIGNOR-100784 |
| PPM1B | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248344 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-236048 |
| TBK1 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-280017 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251276 |
| CHUK | phosphorylation → up-regulates activity | IKBKB | SIGNOR-250771 |
| MAP3K1 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279339 |
| SRC | phosphorylation → up-regulates | IKBKB | SIGNOR-99318 |
| PPM1A | dephosphorylation down-regulates | IKBKB | SIGNOR-181659 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248486 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251284 |
| MAP3K3 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279467 |
| PRKCZ | phosphorylation → up-regulates activity | IKBKB | SIGNOR-249015 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251282 |
| PPP2CB | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248581 |
| SRC | phosphorylation → up-regulates | IKBKB | SIGNOR-99314 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-66344 |
| PPP2CB | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248580 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-251275 |
| PPM1B | dephosphorylation down-regulates | IKBKB | SIGNOR-181667 |