| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | IKBKB | Ser733 | TVREQDQsFTALDWS | phosphorylation down-regulates | 18957422 | SIGNOR-181798 |
| IKBKB | IKBKB | Ser733 | TVREQDQsFTALDWS | phosphorylation down-regulates activity | 10195894 | SIGNOR-66344 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | IKBKB PSer733 | phosphorylation down-regulates ⊣ | IKBKB | 18957422 | SIGNOR-181798 |
| IKBKB | phosphorylation up-regulates → | IKBKB PSer733 | phosphorylation down-regulates ⊣ | IKBKB | 10195894 | SIGNOR-66344 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates | IKBKB | SIGNOR-181798 |
| IKBKB | phosphorylation → down-regulates activity | IKBKB | SIGNOR-66344 |
