| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates | 18930133 | SIGNOR-181659 |
| CHUK | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 10022904 | SIGNOR-250772 |
| PRKCZ | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 10022904 | SIGNOR-249016 |
| PPP2CB | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 19607706 | SIGNOR-248580 |
| PRKAA2 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates | 21673972 | SIGNOR-174405 |
| PDPK1 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 16207722 | SIGNOR-279088 |
| MAP3K7 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 11460167 | SIGNOR-109494 |
| MAP3K3 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 14636585 | SIGNOR-279468 |
| PPM1B | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248344 |
| PPM1A | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248487 |
| PPM1B | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates | 18930133 | SIGNOR-181667 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181659 |
| CHUK | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-250772 |
| PRKCZ | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-249016 |
| PPP2CB | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 19607706 | SIGNOR-248580 |
| PRKAA2 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 21673972 | SIGNOR-174405 |
| PDPK1 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 16207722 | SIGNOR-279088 |
| MAP3K7 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 11460167 | SIGNOR-109494 |
| MAP3K3 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 14636585 | SIGNOR-279468 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248344 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248487 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181667 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1A | dephosphorylation down-regulates | IKBKB | SIGNOR-181659 |
| CHUK | phosphorylation → up-regulates activity | IKBKB | SIGNOR-250772 |
| PRKCZ | phosphorylation → up-regulates activity | IKBKB | SIGNOR-249016 |
| PPP2CB | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248580 |
| PRKAA2 | phosphorylation → up-regulates | IKBKB | SIGNOR-174405 |
| PDPK1 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279088 |
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-109494 |
| MAP3K3 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279468 |
| PPM1B | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248344 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248487 |
| PPM1B | dephosphorylation down-regulates | IKBKB | SIGNOR-181667 |
