| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 11460167 | SIGNOR-109490 |
| CHUK | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 10022904 | SIGNOR-250771 |
| PPM1A | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248486 |
| MAP3K3 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 14636585 | SIGNOR-279467 |
| PRKCZ | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 10022904 | SIGNOR-249015 |
| PPP2CB | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 19607706 | SIGNOR-248581 |
| PRKCE | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 23123196 | SIGNOR-278323 |
| PRKAA2 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates | 21673972 | SIGNOR-174401 |
| PPM1A | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates | 18930133 | SIGNOR-181655 |
| PPM1B | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates | 18930133 | SIGNOR-181663 |
| PPM1B | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248343 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K7 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 11460167 | SIGNOR-109490 |
| CHUK | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-250771 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248486 |
| MAP3K3 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 14636585 | SIGNOR-279467 |
| PRKCZ | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-249015 |
| PPP2CB | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 19607706 | SIGNOR-248581 |
| PRKCE | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 23123196 | SIGNOR-278323 |
| PRKAA2 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 21673972 | SIGNOR-174401 |
| PPM1A | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181655 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181663 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248343 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K7 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-109490 |
| CHUK | phosphorylation → up-regulates activity | IKBKB | SIGNOR-250771 |
| PPM1A | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248486 |
| MAP3K3 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279467 |
| PRKCZ | phosphorylation → up-regulates activity | IKBKB | SIGNOR-249015 |
| PPP2CB | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248581 |
| PRKCE | phosphorylation → up-regulates activity | IKBKB | SIGNOR-278323 |
| PRKAA2 | phosphorylation → up-regulates | IKBKB | SIGNOR-174401 |
| PPM1A | dephosphorylation down-regulates | IKBKB | SIGNOR-181655 |
| PPM1B | dephosphorylation down-regulates | IKBKB | SIGNOR-181663 |
| PPM1B | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248343 |
