| Name | PLD2 |
| ID | O14939 |
| Role | substrate |
| Enzymatic Domains |
PX 65-195 PROSITE-ProRule
PH 203-311
PLD phosphodiesterase 1 437-464 PROSITE-ProRule
PLD phosphodiesterase 2 751-778 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | PLD2 | Thr252 | LLYMCLEtGAISFVQ | phosphorylation up-regulates | 15979581 | SIGNOR-138355 |
| CDK5 | PLD2 | Ser134 | ARFAVAYsPARDAGN | phosphorylation down-regulates activity | 18625302 | SIGNOR-276168 |
| CDK5 | PLD2 | Ser134 | ARFAVAYsPARDAGN | phosphorylation up-regulates activity | 18625302 | SIGNOR-278395 |
| PRKCD | PLD2 | Thr566 | FIQRWNFtKTTKAKY | phosphorylation up-regulates | 20733000 | SIGNOR-167577 |
| EGFR | PLD2 | Tyr179 | RLLTMSFyRNYHAMT | phosphorylation up-regulates activity | 9837959 | SIGNOR-251095 |
| JAK3 | PLD2 | Tyr415 | ALGINSGySKRALML | phosphorylation up-regulates | 20176813 | SIGNOR-163858 |
| PTK2 | PLD2 | – | phosphorylation up-regulates activity | 32843133 | SIGNOR-279480 | |
| PRKCA | PLD2 | Ser243 | RWLVVKDsFLLYMCL | phosphorylation up-regulates | 15979581 | SIGNOR-138351 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | PLD2 PThr252 | phosphorylation up-regulates → | PLD2 | 15979581 | SIGNOR-138355 |
| CDK5 | phosphorylation up-regulates → | PLD2 PSer134 | phosphorylation down-regulates ⊣ | PLD2 | 18625302 | SIGNOR-276168 |
| CDK5 | phosphorylation up-regulates → | PLD2 PSer134 | phosphorylation up-regulates → | PLD2 | 18625302 | SIGNOR-278395 |
| PRKCD | phosphorylation up-regulates → | PLD2 PThr566 | phosphorylation up-regulates → | PLD2 | 20733000 | SIGNOR-167577 |
| EGFR | phosphorylation up-regulates → | PLD2 PTyr179 | phosphorylation up-regulates → | PLD2 | 9837959 | SIGNOR-251095 |
| JAK3 | phosphorylation up-regulates → | PLD2 PTyr415 | phosphorylation up-regulates → | PLD2 | 20176813 | SIGNOR-163858 |
| PRKCA | phosphorylation up-regulates → | PLD2 PSer243 | phosphorylation up-regulates → | PLD2 | 15979581 | SIGNOR-138351 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → up-regulates | PLD2 | SIGNOR-138355 |
| CDK5 | phosphorylation → down-regulates activity | PLD2 | SIGNOR-276168 |
| CDK5 | phosphorylation → up-regulates activity | PLD2 | SIGNOR-278395 |
| PRKCD | phosphorylation → up-regulates | PLD2 | SIGNOR-167577 |
| EGFR | phosphorylation → up-regulates activity | PLD2 | SIGNOR-251095 |
| JAK3 | phosphorylation → up-regulates | PLD2 | SIGNOR-163858 |
| PTK2 | phosphorylation → up-regulates activity | PLD2 | SIGNOR-279480 |
| PRKCA | phosphorylation → up-regulates | PLD2 | SIGNOR-138351 |