| Name | MYL12B |
| ID | O14950 |
| Role | substrate |
| Enzymatic Domains |
EF-hand 1 29-64 PROSITE-ProRule
EF-hand 2 98-133 PROSITE-ProRule
EF-hand 3 134-169 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ILK | MYL12B | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates activity | 11278951 | SIGNOR-106427 |
| ROCK1 | MYL12B | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates | 12185584 | SIGNOR-91542 |
| PAK1 | MYL12B | – | phosphorylation up-regulates activity | 25860930 | SIGNOR-280053 | |
| MAP3K12 | MYL12B | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 11781833 | SIGNOR-113664 |
| DAPK3 | MYL12B | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates | 1178183 | SIGNOR-16043 |
| ILK | MYL12B | Ser20 | KRPQRATsNVFAMFD | phosphorylation up-regulates activity | 11278951 | SIGNOR-106423 |
| ROCK1 | MYL12B | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 12185584 | SIGNOR-91546 |
| ROCK2 | MYL12B | – | phosphorylation up-regulates activity | 25412762 | SIGNOR-279103 | |
| DAPK3 | MYL12B | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 12429016 | SIGNOR-95524 |
| DAPK3 | MYL12B | Thr19 | KKRPQRAtSNVFAMF | phosphorylation up-regulates | 1178183 | SIGNOR-16047 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ILK | phosphorylation up-regulates → | MYL12B PThr19 | phosphorylation up-regulates → | MYL12B | 11278951 | SIGNOR-106427 |
| ROCK1 | phosphorylation up-regulates → | MYL12B PSer20 | phosphorylation up-regulates → | MYL12B | 12185584 | SIGNOR-91542 |
| MAP3K12 | phosphorylation up-regulates → | MYL12B PThr19 | phosphorylation up-regulates → | MYL12B | 11781833 | SIGNOR-113664 |
| DAPK3 | phosphorylation up-regulates → | MYL12B PSer20 | phosphorylation up-regulates → | MYL12B | 1178183 | SIGNOR-16043 |
| ILK | phosphorylation up-regulates → | MYL12B PSer20 | phosphorylation up-regulates → | MYL12B | 11278951 | SIGNOR-106423 |
| ROCK1 | phosphorylation up-regulates → | MYL12B PThr19 | phosphorylation up-regulates → | MYL12B | 12185584 | SIGNOR-91546 |
| DAPK3 | phosphorylation up-regulates → | MYL12B PThr19 | phosphorylation up-regulates → | MYL12B | 12429016 | SIGNOR-95524 |
| DAPK3 | phosphorylation up-regulates → | MYL12B PThr19 | phosphorylation up-regulates → | MYL12B | 1178183 | SIGNOR-16047 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ILK | phosphorylation → up-regulates activity | MYL12B | SIGNOR-106427 |
| ROCK1 | phosphorylation → up-regulates | MYL12B | SIGNOR-91542 |
| PAK1 | phosphorylation → up-regulates activity | MYL12B | SIGNOR-280053 |
| MAP3K12 | phosphorylation → up-regulates | MYL12B | SIGNOR-113664 |
| DAPK3 | phosphorylation → up-regulates | MYL12B | SIGNOR-16043 |
| ILK | phosphorylation → up-regulates activity | MYL12B | SIGNOR-106423 |
| ROCK1 | phosphorylation → up-regulates | MYL12B | SIGNOR-91546 |
| ROCK2 | phosphorylation → up-regulates activity | MYL12B | SIGNOR-279103 |
| DAPK3 | phosphorylation → up-regulates | MYL12B | SIGNOR-95524 |
| DAPK3 | phosphorylation → up-regulates | MYL12B | SIGNOR-16047 |