Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SYK	PIP5K1B	Tyr105	FGIKPDDyLYSICSE	phosphorylation down-regulates activity	19553680	SIGNOR-276227
PRKCA	PIP5K1B	Ser413 View in OncoXplorer	PSKKRCNsIAALKAT	phosphorylation down-regulates	23909401	SIGNOR-194820

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SYK	phosphorylation up-regulates →	PIP5K1B PTyr105	phosphorylation down-regulates ⊣	PIP5K1B	19553680	SIGNOR-276227
PRKCA	phosphorylation up-regulates →	PIP5K1B PSer413	phosphorylation down-regulates ⊣	PIP5K1B	23909401	SIGNOR-194820

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SYK	phosphorylation → down-regulates activity	PIP5K1B	SIGNOR-276227
PRKCA	phosphorylation down-regulates	PIP5K1B	SIGNOR-194820