| Name | CHUK |
| ID | O15111 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 15-302 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | CREBBP | Ser1382 | MKSRFVDsGEMSESF | phosphorylation up-regulates | 17434128 | SIGNOR-154329 |
| CHUK | RIPK1 | – | phosphorylation down-regulates activity | 26516792 | SIGNOR-278927 | |
| CHUK | NfKb-p65/p50 | – | phosphorylation down-regulates | 10469655 | SIGNOR-217397 | |
| CHUK | FOXA2 | Ser107 | AGMGPHLsPSLSPLG | phosphorylation down-regulates | 22196886 | SIGNOR-195312 |
| CHUK | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70449 |
| CHUK | TAX1BP1 | Ser666 | RPPVRVPsWGLEDNV | phosphorylation up-regulates activity | 21765415 | SIGNOR-175062 |
| CHUK | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235438 |
| CHUK | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 10022904 | SIGNOR-250771 |
| CHUK | NPM1 | Ser125 | AVEEDAEsEDEEEED | phosphorylation up-regulates activity | 24290756 | SIGNOR-279405 |
| CHUK | CYLD | Ser436 | TNGSIGHsPLSLSAQ | phosphorylation down-regulates activity | 24614225 | SIGNOR-204700 |
| CHUK | IRF5 | – | phosphorylation down-regulates activity | 19786094 | SIGNOR-278293 | |
| CHUK | MTURN | Ser58 | GDNFHVWsESEDCLP | phosphorylation down-regulates activity | 28704656 | SIGNOR-273612 |
| CHUK | BCL3 | Ser454 | PSPAPGGs | phosphorylation up-regulates activity | 28689659 | SIGNOR-277363 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 10521409 | SIGNOR-71270 |
| CHUK | PIAS1 | Ser90 | SPMPATLsPSTIPQL | phosphorylation up-regulates activity | 17540171 | SIGNOR-278926 |
| CHUK | CREBBP | Ser1386 | FVDSGEMsESFPYRT | phosphorylation up-regulates | 17434128 | SIGNOR-154333 |
| CHUK | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235442 |
| CHUK | MECP2 | Ser423 | EKMPRGGsLESDGCP | phosphorylation up-regulates activity | 22848609 | SIGNOR-279459 |
| CHUK | CYLD | Ser439 | SIGHSPLsLSAQSVM | phosphorylation down-regulates activity | 24614225 | SIGNOR-204704 |
| CHUK | NCOR2 | Ser2407 | AKVSGRPsSRKAKSP | phosphorylation down-regulates | 15494311 | SIGNOR-129956 |
| CHUK | CYLD | Ser444 | PLSLSAQsVMEELNT | phosphorylation down-regulates activity | 24614225 | SIGNOR-204712 |
| CHUK | FOXA2 | Ser111 | PHLSPSLsPLGGQAA | phosphorylation down-regulates | 22196886 | SIGNOR-195316 |
| CHUK | CTNNB1 | – | phosphorylation up-regulates quantity | 22435559 | SIGNOR-280230 | |
| CHUK | AMBRA1 | Ser1043 | CRPEALNsGVEYYWD | phosphorylation up-regulates activity | 30217973 | SIGNOR-272974 |
| CHUK | TP73 | – | phosphorylation up-regulates activity | 22084676 | SIGNOR-279697 | |
| CHUK | BCL3 | Ser122 | CPMEHPLsADIAMAT | phosphorylation up-regulates activity | 28689659 | SIGNOR-277362 |
| CHUK | COPS5 | Thr205 | EGPSEYQtIPLNKIE | phosphorylation down-regulates activity | 31950832 | SIGNOR-275508 |
| CHUK | STAT1 | – | phosphorylation up-regulates activity | 27992555 | SIGNOR-279732 | |
| CHUK | NFKB1 | Ser927 | DSDSVCDsGVETSFR | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70453 |
| CHUK | ELAVL1 | Ser304 | EAAMAIAsLNGYRLG | phosphorylation down-regulates quantity by destabilization | 23115237 | SIGNOR-276422 |
| CHUK | MAP3K14 | Thr559 | TGDYIPGtETHMAPE | phosphorylation down-regulates quantity by destabilization | 20501937 | SIGNOR-165622 |
| CHUK | CYLD | Ser432 | KMPNTNGsIGHSPLS | phosphorylation down-regulates activity | 24614225 | SIGNOR-204696 |
| CHUK | NFKB2 | Ser866 | TAEVKEDsAYGSQSV | phosphorylation up-regulates activity | 15084608 | SIGNOR-124226 |
| CHUK | CDKN1B | Ser183 | DGSPNAGsVEQTPKK | phosphorylation down-regulates activity | 23602409 | SIGNOR-278438 |
| CHUK | TAX1BP1 | Ser593 | NYKELKRsLENPAER | phosphorylation up-regulates activity | 21765415 | SIGNOR-175058 |
| CHUK | ESR1 | Ser118 | LHPPPQLsPFLQPHG | phosphorylation up-regulates activity | 15808510 | SIGNOR-279696 |
| CHUK | IRF7 | – | phosphorylation up-regulates | 16612387 | SIGNOR-146116 | |
| CHUK | COPS5 | Ser201 | KPPDEGPsEYQTIPL | phosphorylation down-regulates activity | 31950832 | SIGNOR-275507 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15489227 | SIGNOR-129931 |
| CHUK | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 15383283 | SIGNOR-127064 |
| CHUK | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 10022904 | SIGNOR-250772 |
| CHUK | NFKB1 | Thr931 | VCDSGVEtSFRKLSF | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70461 |
| CHUK | NFKB1 | Ser923 | DELRDSDsVCDSGVE | phosphorylation down-regulates quantity by destabilization | 11297557 | SIGNOR-235434 |
| CHUK | KHDRBS1 | – | phosphorylation up-regulates activity | 23715268 | SIGNOR-278439 | |
| CHUK | CYLD | Ser441 | GHSPLSLsAQSVMEE | phosphorylation up-regulates activity | 24614225 | SIGNOR-204708 |
| CHUK | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 9346241 | SIGNOR-52879 |
| CHUK | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 23343355 | SIGNOR-280231 |
| CHUK | FOXO | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-252893 |
| CHUK | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 24614225 | SIGNOR-204688 |
| CHUK | MTOR | Ser1415 | PTPAILEsLISINNK | phosphorylation up-regulates activity | 24990947 | SIGNOR-276646 |
| CHUK | TRAF4 | Ser426 | KPGTWRGsLDESSLG | phosphorylation down-regulates | 22547678 | SIGNOR-197253 |
| CHUK | MTOR | – | phosphorylation up-regulates activity | 27027448 | SIGNOR-279607 | |
| CHUK | CYLD | Ser422 | RFHSLPFsLTKMPNT | phosphorylation up-regulates activity | 24614225 | SIGNOR-204692 |
| CHUK | CCND1 | Thr286 | EEVDLACtPTDVRDV | phosphorylation down-regulates | 16103118 | SIGNOR-139570 |
| CHUK | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates quantity by destabilization | 9346241 | SIGNOR-52875 |
| CHUK | TSC2 | – | phosphorylation down-regulates | 18490760 | SIGNOR-178664 | |
| CHUK | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 22505454 | SIGNOR-196953 |
| CHUK | NFKB2 | Ser870 | KEDSAYGsQSVEQEA | phosphorylation up-regulates activity | 15084608 | SIGNOR-124230 |
| CHUK | NFKB1 | Ser932 | CDSGVETsFRKLSFT | phosphorylation down-regulates quantity by destabilization | 10469655 | SIGNOR-70457 |
| CHUK | NCOA3 | – | phosphorylation up-regulates | 15808510 | SIGNOR-135050 | |
| CHUK | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-124203 |
| CHUK | RELA | Ser536 | SGDEDFSsIADMDFS | phosphorylation up-regulates activity | 15611276 | SIGNOR-132568 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | phosphorylation up-regulates → | CREBBP PSer1382 | phosphorylation up-regulates → | CREBBP | 17434128 | SIGNOR-154329 |
| CHUK | phosphorylation up-regulates → | FOXA2 PSer107 | phosphorylation down-regulates ⊣ | FOXA2 | 22196886 | SIGNOR-195312 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70449 |
| CHUK | phosphorylation up-regulates → | TAX1BP1 PSer666 | phosphorylation up-regulates → | TAX1BP1 | 21765415 | SIGNOR-175062 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235438 |
| CHUK | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-250771 |
| CHUK | phosphorylation up-regulates → | NPM1 PSer125 | phosphorylation up-regulates → | NPM1 | 24290756 | SIGNOR-279405 |
| CHUK | phosphorylation up-regulates → | CYLD PSer436 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204700 |
| CHUK | phosphorylation up-regulates → | MTURN PSer58 | phosphorylation down-regulates ⊣ | MTURN | 28704656 | SIGNOR-273612 |
| CHUK | phosphorylation up-regulates → | BCL3 PSer454 | phosphorylation up-regulates → | BCL3 | 28689659 | SIGNOR-277363 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 10521409 | SIGNOR-71270 |
| CHUK | phosphorylation up-regulates → | PIAS1 PSer90 | phosphorylation up-regulates → | PIAS1 | 17540171 | SIGNOR-278926 |
| CHUK | phosphorylation up-regulates → | CREBBP PSer1386 | phosphorylation up-regulates → | CREBBP | 17434128 | SIGNOR-154333 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235442 |
| CHUK | phosphorylation up-regulates → | MECP2 PSer423 | phosphorylation up-regulates → | MECP2 | 22848609 | SIGNOR-279459 |
| CHUK | phosphorylation up-regulates → | CYLD PSer439 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204704 |
| CHUK | phosphorylation up-regulates → | NCOR2 PSer2407 | phosphorylation down-regulates ⊣ | NCOR2 | 15494311 | SIGNOR-129956 |
| CHUK | phosphorylation up-regulates → | CYLD PSer444 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204712 |
| CHUK | phosphorylation up-regulates → | FOXA2 PSer111 | phosphorylation down-regulates ⊣ | FOXA2 | 22196886 | SIGNOR-195316 |
| CHUK | phosphorylation up-regulates → | AMBRA1 PSer1043 | phosphorylation up-regulates → | AMBRA1 | 30217973 | SIGNOR-272974 |
| CHUK | phosphorylation up-regulates → | BCL3 PSer122 | phosphorylation up-regulates → | BCL3 | 28689659 | SIGNOR-277362 |
| CHUK | phosphorylation up-regulates → | COPS5 PThr205 | phosphorylation down-regulates ⊣ | COPS5 | 31950832 | SIGNOR-275508 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer927 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70453 |
| CHUK | phosphorylation up-regulates → | ELAVL1 PSer304 | phosphorylation down-regulates ⊣ | ELAVL1 | 23115237 | SIGNOR-276422 |
| CHUK | phosphorylation up-regulates → | MAP3K14 PThr559 | phosphorylation down-regulates ⊣ | MAP3K14 | 20501937 | SIGNOR-165622 |
| CHUK | phosphorylation up-regulates → | CYLD PSer432 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204696 |
| CHUK | phosphorylation up-regulates → | NFKB2 PSer866 | phosphorylation up-regulates → | NFKB2 | 15084608 | SIGNOR-124226 |
| CHUK | phosphorylation up-regulates → | CDKN1B PSer183 | phosphorylation down-regulates ⊣ | CDKN1B | 23602409 | SIGNOR-278438 |
| CHUK | phosphorylation up-regulates → | TAX1BP1 PSer593 | phosphorylation up-regulates → | TAX1BP1 | 21765415 | SIGNOR-175058 |
| CHUK | phosphorylation up-regulates → | ESR1 PSer118 | phosphorylation up-regulates → | ESR1 | 15808510 | SIGNOR-279696 |
| CHUK | phosphorylation up-regulates → | COPS5 PSer201 | phosphorylation down-regulates ⊣ | COPS5 | 31950832 | SIGNOR-275507 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15489227 | SIGNOR-129931 |
| CHUK | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-127064 |
| CHUK | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 10022904 | SIGNOR-250772 |
| CHUK | phosphorylation up-regulates → | NFKB1 PThr931 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70461 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer923 | phosphorylation down-regulates ⊣ | NFKB1 | 11297557 | SIGNOR-235434 |
| CHUK | phosphorylation up-regulates → | CYLD PSer441 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204708 |
| CHUK | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-52879 |
| CHUK | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 23343355 | SIGNOR-280231 |
| CHUK | phosphorylation up-regulates → | FOXO PSer644 | phosphorylation down-regulates ⊣ | FOXO | 15084260 | SIGNOR-252893 |
| CHUK | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 24614225 | SIGNOR-204688 |
| CHUK | phosphorylation up-regulates → | MTOR PSer1415 | phosphorylation up-regulates → | MTOR | 24990947 | SIGNOR-276646 |
| CHUK | phosphorylation up-regulates → | TRAF4 PSer426 | phosphorylation down-regulates ⊣ | TRAF4 | 22547678 | SIGNOR-197253 |
| CHUK | phosphorylation up-regulates → | CYLD PSer422 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-204692 |
| CHUK | phosphorylation up-regulates → | CCND1 PThr286 | phosphorylation down-regulates ⊣ | CCND1 | 16103118 | SIGNOR-139570 |
| CHUK | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-52875 |
| CHUK | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 22505454 | SIGNOR-196953 |
| CHUK | phosphorylation up-regulates → | NFKB2 PSer870 | phosphorylation up-regulates → | NFKB2 | 15084608 | SIGNOR-124230 |
| CHUK | phosphorylation up-regulates → | NFKB1 PSer932 | phosphorylation down-regulates ⊣ | NFKB1 | 10469655 | SIGNOR-70457 |
| CHUK | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-124203 |
| CHUK | phosphorylation up-regulates → | RELA PSer536 | phosphorylation up-regulates → | RELA | 15611276 | SIGNOR-132568 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHUK | phosphorylation → up-regulates | CREBBP | SIGNOR-154329 |
| CHUK | phosphorylation → down-regulates activity | RIPK1 | SIGNOR-278927 |
| CHUK | phosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217397 |
| CHUK | phosphorylation down-regulates | FOXA2 | SIGNOR-195312 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70449 |
| CHUK | phosphorylation → up-regulates activity | TAX1BP1 | SIGNOR-175062 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235438 |
| CHUK | phosphorylation → up-regulates activity | IKBKB | SIGNOR-250771 |
| CHUK | phosphorylation → up-regulates activity | NPM1 | SIGNOR-279405 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204700 |
| CHUK | phosphorylation → down-regulates activity | IRF5 | SIGNOR-278293 |
| CHUK | phosphorylation → down-regulates activity | MTURN | SIGNOR-273612 |
| CHUK | phosphorylation → up-regulates activity | BCL3 | SIGNOR-277363 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-71270 |
| CHUK | phosphorylation → up-regulates activity | PIAS1 | SIGNOR-278926 |
| CHUK | phosphorylation → up-regulates | CREBBP | SIGNOR-154333 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235442 |
| CHUK | phosphorylation → up-regulates activity | MECP2 | SIGNOR-279459 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204704 |
| CHUK | phosphorylation down-regulates | NCOR2 | SIGNOR-129956 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204712 |
| CHUK | phosphorylation down-regulates | FOXA2 | SIGNOR-195316 |
| CHUK | phosphorylation → up-regulates quantity | CTNNB1 | SIGNOR-280230 |
| CHUK | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-272974 |
| CHUK | phosphorylation → up-regulates activity | TP73 | SIGNOR-279697 |
| CHUK | phosphorylation → up-regulates activity | BCL3 | SIGNOR-277362 |
| CHUK | phosphorylation → down-regulates activity | COPS5 | SIGNOR-275508 |
| CHUK | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279732 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70453 |
| CHUK | phosphorylation down-regulates quantity by destabilization | ELAVL1 | SIGNOR-276422 |
| CHUK | phosphorylation down-regulates quantity by destabilization | MAP3K14 | SIGNOR-165622 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204696 |
| CHUK | phosphorylation → up-regulates activity | NFKB2 | SIGNOR-124226 |
| CHUK | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-278438 |
| CHUK | phosphorylation → up-regulates activity | TAX1BP1 | SIGNOR-175058 |
| CHUK | phosphorylation → up-regulates activity | ESR1 | SIGNOR-279696 |
| CHUK | phosphorylation → up-regulates | IRF7 | SIGNOR-146116 |
| CHUK | phosphorylation → down-regulates activity | COPS5 | SIGNOR-275507 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-129931 |
| CHUK | phosphorylation → up-regulates | NCOA3 | SIGNOR-127064 |
| CHUK | phosphorylation → up-regulates activity | IKBKB | SIGNOR-250772 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70461 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-235434 |
| CHUK | phosphorylation → up-regulates activity | KHDRBS1 | SIGNOR-278439 |
| CHUK | phosphorylation → up-regulates activity | CYLD | SIGNOR-204708 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-52879 |
| CHUK | phosphorylation → up-regulates activity | TP53 | SIGNOR-280231 |
| CHUK | phosphorylation down-regulates | FOXO | SIGNOR-252893 |
| CHUK | phosphorylation → down-regulates activity | CYLD | SIGNOR-204688 |
| CHUK | phosphorylation → up-regulates activity | MTOR | SIGNOR-276646 |
| CHUK | phosphorylation down-regulates | TRAF4 | SIGNOR-197253 |
| CHUK | phosphorylation → up-regulates activity | MTOR | SIGNOR-279607 |
| CHUK | phosphorylation → up-regulates activity | CYLD | SIGNOR-204692 |
| CHUK | phosphorylation down-regulates | CCND1 | SIGNOR-139570 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-52875 |
| CHUK | phosphorylation down-regulates | TSC2 | SIGNOR-178664 |
| CHUK | phosphorylation → up-regulates | NCOA3 | SIGNOR-196953 |
| CHUK | phosphorylation → up-regulates activity | NFKB2 | SIGNOR-124230 |
| CHUK | phosphorylation down-regulates quantity by destabilization | NFKB1 | SIGNOR-70457 |
| CHUK | phosphorylation → up-regulates | NCOA3 | SIGNOR-135050 |
| CHUK | phosphorylation down-regulates | FOXO3 | SIGNOR-124203 |
| CHUK | phosphorylation → up-regulates activity | RELA | SIGNOR-132568 |