| Name | CHUK |
| ID | O15111 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 15-302 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-244210 |
| MAP3K14 | CHUK | Ser180 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 9520446 | SIGNOR-55946 |
| MAP3K21 | CHUK | – | phosphorylation down-regulates activity | 26859459 | SIGNOR-279067 | |
| AKT2 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-187010 |
| AKT3 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-187062 |
| SGK1 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates activity | 19088076 | SIGNOR-278987 |
| MAP3K14 | CHUK | – | phosphorylation up-regulates activity | 20651737 | SIGNOR-167060 | |
| AKT1 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates | 19609947 | SIGNOR-187006 |
| MAP3K14 | CHUK | Ser176 | AKDVDQGsLCTSFVG | phosphorylation up-regulates activity | 9520446 | SIGNOR-55942 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-244210 |
| MAP3K14 | phosphorylation up-regulates → | CHUK PSer180 | phosphorylation up-regulates → | CHUK | 9520446 | SIGNOR-55946 |
| AKT2 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-187010 |
| AKT3 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-187062 |
| SGK1 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19088076 | SIGNOR-278987 |
| AKT1 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19609947 | SIGNOR-187006 |
| MAP3K14 | phosphorylation up-regulates → | CHUK PSer176 | phosphorylation up-regulates → | CHUK | 9520446 | SIGNOR-55942 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → up-regulates | CHUK | SIGNOR-244210 |
| MAP3K14 | phosphorylation → up-regulates activity | CHUK | SIGNOR-55946 |
| MAP3K21 | phosphorylation → down-regulates activity | CHUK | SIGNOR-279067 |
| AKT2 | phosphorylation → up-regulates | CHUK | SIGNOR-187010 |
| AKT3 | phosphorylation → up-regulates | CHUK | SIGNOR-187062 |
| SGK1 | phosphorylation → up-regulates activity | CHUK | SIGNOR-278987 |
| MAP3K14 | phosphorylation → up-regulates activity | CHUK | SIGNOR-167060 |
| AKT1 | phosphorylation → up-regulates | CHUK | SIGNOR-187006 |
| MAP3K14 | phosphorylation → up-regulates activity | CHUK | SIGNOR-55942 |