| Name | MDM4 |
| ID | O15151 |
| Role | substrate |
| Enzymatic Domains |
SWIB/MDM2 25-108 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | MDM4 | Ser403 | DLAHSSEsQETISSM | dephosphorylation up-regulates quantity by stabilization | 33309518 | SIGNOR-275491 |
| ATM | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates | 16943424 | SIGNOR-149292 |
| CHEK2 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 18356162 | SIGNOR-178071 |
| CHEK1 | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates activity | 16163388 | SIGNOR-250770 |
| PPM1D | MDM4 | Ser403 | DLAHSSEsQETISSM | dephosphorylation up-regulates quantity by stabilization | 19808970 | SIGNOR-276951 |
| CDK1 | MDM4 | Ser96 | SFSVKDPsPLYDMLR | phosphorylation down-regulates | 15735705 | SIGNOR-134388 |
| AKT | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation up-regulates activity | 18356162 | SIGNOR-178063 |
| AKT1 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation up-regulates quantity by stabilization | 18356162 | SIGNOR-252517 |
| ATM | MDM4 | Ser403 | DLAHSSEsQETISSM | phosphorylation down-regulates | 16943424 | SIGNOR-149300 |
| ATM | MDM4 | – | phosphorylation down-regulates | 16082221 | SIGNOR-139403 | |
| CSNK1A1 | MDM4 | Ser289 | DDLEDSKsLSDDTDV | phosphorylation up-regulates | 23028042 | SIGNOR-199015 |
| ATM | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 16943424 | SIGNOR-149296 |
| CHEK2 | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates | 16163388 | SIGNOR-140417 |
| CHEK1 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 18356162 | SIGNOR-178067 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | MDM4 PSer403 | dephosphorylation down-regulates ⊣ | MDM4 | 33309518 | SIGNOR-275491 |
| ATM | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16943424 | SIGNOR-149292 |
| CHEK2 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 18356162 | SIGNOR-178071 |
| CHEK1 | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16163388 | SIGNOR-250770 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM4 PSer403 | dephosphorylation down-regulates ⊣ | MDM4 | 19808970 | SIGNOR-276951 |
| CDK1 | phosphorylation up-regulates → | MDM4 PSer96 | phosphorylation down-regulates ⊣ | MDM4 | 15735705 | SIGNOR-134388 |
| AKT | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation up-regulates → | MDM4 | 18356162 | SIGNOR-178063 |
| AKT1 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation up-regulates → | MDM4 | 18356162 | SIGNOR-252517 |
| ATM | phosphorylation up-regulates → | MDM4 PSer403 | phosphorylation down-regulates ⊣ | MDM4 | 16943424 | SIGNOR-149300 |
| CSNK1A1 | phosphorylation up-regulates → | MDM4 PSer289 | phosphorylation up-regulates → | MDM4 | 23028042 | SIGNOR-199015 |
| ATM | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 16943424 | SIGNOR-149296 |
| CHEK2 | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16163388 | SIGNOR-140417 |
| CHEK1 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 18356162 | SIGNOR-178067 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-275491 |
| ATM | phosphorylation down-regulates | MDM4 | SIGNOR-149292 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-178071 |
| CHEK1 | phosphorylation → down-regulates activity | MDM4 | SIGNOR-250770 |
| PPM1D | dephosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-276951 |
| CDK1 | phosphorylation down-regulates | MDM4 | SIGNOR-134388 |
| AKT | phosphorylation → up-regulates activity | MDM4 | SIGNOR-178063 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-252517 |
| ATM | phosphorylation down-regulates | MDM4 | SIGNOR-149300 |
| ATM | phosphorylation down-regulates | MDM4 | SIGNOR-139403 |
| CSNK1A1 | phosphorylation → up-regulates | MDM4 | SIGNOR-199015 |
| ATM | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-149296 |
| CHEK2 | phosphorylation down-regulates | MDM4 | SIGNOR-140417 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-178067 |