| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates | 16163388 | SIGNOR-140417 |
| ATM | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates | 16943424 | SIGNOR-149292 |
| CHEK1 | MDM4 | Ser342 | SKLTHSLsTSDITAI | phosphorylation down-regulates activity | 16163388 | SIGNOR-250770 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK2 | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16163388 | SIGNOR-140417 |
| ATM | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16943424 | SIGNOR-149292 |
| CHEK1 | phosphorylation up-regulates → | MDM4 PSer342 | phosphorylation down-regulates ⊣ | MDM4 | 16163388 | SIGNOR-250770 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK2 | phosphorylation![]() down-regulates | MDM4 | SIGNOR-140417 |
| ATM | phosphorylation![]() down-regulates | MDM4 | SIGNOR-149292 |
| CHEK1 | phosphorylation → down-regulates activity | MDM4 | SIGNOR-250770 |