| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | MDM4 | Ser403 | DLAHSSEsQETISSM | dephosphorylation up-regulates quantity by stabilization | 33309518 | SIGNOR-275491 |
| PPM1D | MDM4 | Ser403 | DLAHSSEsQETISSM | dephosphorylation up-regulates quantity by stabilization | 19808970 | SIGNOR-276951 |
| ATM | MDM4 | Ser403 | DLAHSSEsQETISSM | phosphorylation down-regulates | 16943424 | SIGNOR-149300 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1D | dephosphorylation down-regulates ⊣ | MDM4 PSer403 | dephosphorylation down-regulates ⊣ | MDM4 | 33309518 | SIGNOR-275491 |
| PPM1D | dephosphorylation down-regulates ⊣ | MDM4 PSer403 | dephosphorylation down-regulates ⊣ | MDM4 | 19808970 | SIGNOR-276951 |
| ATM | phosphorylation up-regulates → | MDM4 PSer403 | phosphorylation down-regulates ⊣ | MDM4 | 16943424 | SIGNOR-149300 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1D | dephosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-275491 |
| PPM1D | dephosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-276951 |
| ATM | phosphorylation down-regulates | MDM4 | SIGNOR-149300 |
