| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 16943424 | SIGNOR-149296 |
| CHEK1 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 18356162 | SIGNOR-178067 |
| CHEK2 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation down-regulates quantity by destabilization | 18356162 | SIGNOR-178071 |
| AKT | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation up-regulates activity | 18356162 | SIGNOR-178063 |
| AKT1 | MDM4 | Ser367 | PDCRRTIsAPVVRPK | phosphorylation up-regulates quantity by stabilization | 18356162 | SIGNOR-252517 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 16943424 | SIGNOR-149296 |
| CHEK1 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 18356162 | SIGNOR-178067 |
| CHEK2 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation down-regulates ⊣ | MDM4 | 18356162 | SIGNOR-178071 |
| AKT | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation up-regulates → | MDM4 | 18356162 | SIGNOR-178063 |
| AKT1 | phosphorylation up-regulates → | MDM4 PSer367 | phosphorylation up-regulates → | MDM4 | 18356162 | SIGNOR-252517 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-149296 |
| CHEK1 | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-178067 |
| CHEK2 | phosphorylation down-regulates quantity by destabilization | MDM4 | SIGNOR-178071 |
| AKT | phosphorylation → up-regulates activity | MDM4 | SIGNOR-178063 |
| AKT1 | phosphorylation → up-regulates quantity by stabilization | MDM4 | SIGNOR-252517 |
