| Name | AXIN1 |
| ID | O15169 |
| Role | substrate |
| Enzymatic Domains |
RGS 88-211 PROSITE-ProRule
DIX 780-862 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248552 |
| PPP1CC | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248497 |
| PPP1CA | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248554 |
| PPP1CB | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248570 |
| PPP1CC | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248495 |
| PPP1CB | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248568 |
| GSK3B | AXIN1 | – | phosphorylation up-regulates | 23579495 | SIGNOR-201683 | |
| PPP1CB | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248569 |
| PPP1CB | AXIN1 | Ser75 | LGYEPEGsASPTPPY | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248567 |
| PPP1CA | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248553 |
| CSNK1A1 | AXIN1 | Ser469 | AHEENPEsILDEHVQ | phosphorylation up-regulates activity | 17318175 | SIGNOR-249192 |
| GSK3B | AXIN1 | Thr481 | HVQRVLRtPGRQSPG | phosphorylation up-regulates activity | 10581160 | SIGNOR-251222 |
| PPP1CC | AXIN1 | Ser75 | LGYEPEGsASPTPPY | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248494 |
| PPM1A | AXIN1 | – | dephosphorylation down-regulates quantity by destabilization | 10644691 | SIGNOR-248488 | |
| PP1 | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-264660 |
| CSNK1D | AXIN1 | Ser46 | PASYSFCsGKGVGIK | phosphorylation up-regulates | 12000790 | SIGNOR-87437 |
| CSNK1A1 | AXIN1 | Ser77 | YEPEGSAsPTPPYLK | phosphorylation up-regulates activity | 17318175 | SIGNOR-249191 |
| CSNK1E | AXIN1 | – | phosphorylation up-regulates | 12000790 | SIGNOR-87444 | |
| PPP1CC | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248496 |
| GSK3B | AXIN1 | Ser486 | LRTPGRQsPGPGHRS | phosphorylation up-regulates activity | 10581160 | SIGNOR-251221 |
| CSNK1A1 | AXIN1 | Ser75 | LGYEPEGsASPTPPY | phosphorylation up-regulates activity | 17318175 | SIGNOR-249189 |
| PPM1A | AXIN1 | – | dephosphorylation down-regulates | 10644691 | SIGNOR-74231 | |
| PPP1CA | AXIN1 | Ser75 | LGYEPEGsASPTPPY | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248551 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer77 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248552 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248497 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248554 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248570 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer77 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248495 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer77 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248568 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248569 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer75 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248567 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248553 |
| CSNK1A1 | phosphorylation up-regulates → | AXIN1 PSer469 | phosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-249192 |
| GSK3B | phosphorylation up-regulates → | AXIN1 PThr481 | phosphorylation up-regulates → | AXIN1 | 10581160 | SIGNOR-251222 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer75 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248494 |
| PP1 | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-264660 |
| CSNK1D | phosphorylation up-regulates → | AXIN1 PSer46 | phosphorylation up-regulates → | AXIN1 | 12000790 | SIGNOR-87437 |
| CSNK1A1 | phosphorylation up-regulates → | AXIN1 PSer77 | phosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-249191 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248496 |
| GSK3B | phosphorylation up-regulates → | AXIN1 PSer486 | phosphorylation up-regulates → | AXIN1 | 10581160 | SIGNOR-251221 |
| CSNK1A1 | phosphorylation up-regulates → | AXIN1 PSer75 | phosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-249189 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer75 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248551 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248552 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248497 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248554 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248570 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248495 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248568 |
| GSK3B | phosphorylation → up-regulates | AXIN1 | SIGNOR-201683 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248569 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248567 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248553 |
| CSNK1A1 | phosphorylation → up-regulates activity | AXIN1 | SIGNOR-249192 |
| GSK3B | phosphorylation → up-regulates activity | AXIN1 | SIGNOR-251222 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248494 |
| PPM1A | dephosphorylation down-regulates quantity by destabilization | AXIN1 | SIGNOR-248488 |
| PP1 | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-264660 |
| CSNK1D | phosphorylation → up-regulates | AXIN1 | SIGNOR-87437 |
| CSNK1A1 | phosphorylation → up-regulates activity | AXIN1 | SIGNOR-249191 |
| CSNK1E | phosphorylation → up-regulates | AXIN1 | SIGNOR-87444 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248496 |
| GSK3B | phosphorylation → up-regulates activity | AXIN1 | SIGNOR-251221 |
| CSNK1A1 | phosphorylation → up-regulates activity | AXIN1 | SIGNOR-249189 |
| PPM1A | dephosphorylation down-regulates | AXIN1 | SIGNOR-74231 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248551 |