Entity Details

Name	AXIN1_Ser77
ID	O15169
Role	residue
View in

Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PPP1CA	AXIN1	Ser77 View in OncoXplorer	YEPEGSAsPTPPYLK	dephosphorylation down-regulates activity	17318175	SIGNOR-248552
CSNK1A1	AXIN1	Ser77 View in OncoXplorer	YEPEGSAsPTPPYLK	phosphorylation up-regulates activity	17318175	SIGNOR-249191
PPP1CC	AXIN1	Ser77 View in OncoXplorer	YEPEGSAsPTPPYLK	dephosphorylation down-regulates activity	17318175	SIGNOR-248495
PPP1CB	AXIN1	Ser77 View in OncoXplorer	YEPEGSAsPTPPYLK	dephosphorylation down-regulates activity	17318175	SIGNOR-248568

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PPP1CA	dephosphorylation down-regulates ⊣	AXIN1 PSer77	dephosphorylation up-regulates →	AXIN1	17318175	SIGNOR-248552
CSNK1A1	phosphorylation up-regulates →	AXIN1 PSer77	phosphorylation up-regulates →	AXIN1	17318175	SIGNOR-249191
PPP1CC	dephosphorylation down-regulates ⊣	AXIN1 PSer77	dephosphorylation up-regulates →	AXIN1	17318175	SIGNOR-248495
PPP1CB	dephosphorylation down-regulates ⊣	AXIN1 PSer77	dephosphorylation up-regulates →	AXIN1	17318175	SIGNOR-248568

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PPP1CA	dephosphorylation → down-regulates activity	AXIN1	SIGNOR-248552
CSNK1A1	phosphorylation → up-regulates activity	AXIN1	SIGNOR-249191
PPP1CC	dephosphorylation → down-regulates activity	AXIN1	SIGNOR-248495
PPP1CB	dephosphorylation → down-regulates activity	AXIN1	SIGNOR-248568