| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CC | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248497 |
| PPP1CA | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248554 |
| PPP1CB | AXIN1 | Ser469 | AHEENPEsILDEHVQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248570 |
| CSNK1A1 | AXIN1 | Ser469 | AHEENPEsILDEHVQ | phosphorylation up-regulates activity | 17318175 | SIGNOR-249192 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248497 |
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248554 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer469 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248570 |
| CSNK1A1 | phosphorylation up-regulates → | AXIN1 PSer469 | phosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-249192 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248497 |
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248554 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248570 |
| CSNK1A1 | phosphorylation → up-regulates activity | AXIN1 | SIGNOR-249192 |