| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248553 |
| PP1 | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-264660 |
| PPP1CC | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248496 |
| PPP1CB | AXIN1 | Ser217 | YTRTGSEsPKVCSDQ | dephosphorylation down-regulates activity | 17318175 | SIGNOR-248569 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP1CA | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248553 |
| PP1 | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-264660 |
| PPP1CC | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248496 |
| PPP1CB | dephosphorylation down-regulates ⊣ | AXIN1 PSer217 | dephosphorylation up-regulates → | AXIN1 | 17318175 | SIGNOR-248569 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP1CA | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248553 |
| PP1 | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-264660 |
| PPP1CC | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248496 |
| PPP1CB | dephosphorylation → down-regulates activity | AXIN1 | SIGNOR-248569 |