Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CTDSPL	RB1	Ser807	PGGNIYIsPLKSPYK	dephosphorylation up-regulates activity	15051889	SIGNOR-248304
CTDSPL	RB1	Ser811	IYISPLKsPYKISEG	dephosphorylation up-regulates activity	15051889	SIGNOR-248305
CTDSPL	SMAD3	Ser204	NHSMDAGsPNLSPNP	dephosphorylation up-regulates activity	17035229	SIGNOR-248306
CTDSPL	SMAD3	Ser208	DAGSPNLsPNPMSPA	dephosphorylation up-regulates activity	17035229	SIGNOR-248307
CTDSPL	SMAD3	Ser213	NLSPNPMsPAHNNLD	dephosphorylation up-regulates activity	17035229	SIGNOR-248308
CTDSPL	SMAD2	Ser245	NQSMDTGsPAELSPT	dephosphorylation down-regulates activity	17035229	SIGNOR-248310
CTDSPL	SMAD2	Ser250	TGSPAELsPTTLSPV	dephosphorylation down-regulates activity	17035229	SIGNOR-248311
CTDSPL	SMAD2	Ser255	ELSPTTLsPVNHSLD	dephosphorylation down-regulates activity	17035229	SIGNOR-248312
CTDSPL	SMAD2	Thr220	QSNYIPEtPPPGYIS	dephosphorylation down-regulates activity	17035229	SIGNOR-248309
CTDSPL	SMAD1	Ser187	NSHPFPHsPNSSYPN	dephosphorylation down-regulates activity	17085434	SIGNOR-248313
CTDSPL	SMAD1	Ser195	PNSSYPNsPGSSSST	dephosphorylation down-regulates activity	17085434	SIGNOR-248314
CTDSPL	SMAD1	Ser206	SSSTYPHsPTSSDPG	dephosphorylation down-regulates activity	17085434	SIGNOR-248315
CTDSPL	SMAD1	Ser214	PTSSDPGsPFQMPAD	dephosphorylation down-regulates activity	17085434	SIGNOR-248316

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CTDSPL	dephosphorylation down-regulates ⊣	RB1 PSer807	dephosphorylation down-regulates ⊣	RB1	15051889	SIGNOR-248304
CTDSPL	dephosphorylation down-regulates ⊣	RB1 PSer811	dephosphorylation down-regulates ⊣	RB1	15051889	SIGNOR-248305
CTDSPL	dephosphorylation down-regulates ⊣	SMAD3 PSer204	dephosphorylation down-regulates ⊣	SMAD3	17035229	SIGNOR-248306
CTDSPL	dephosphorylation down-regulates ⊣	SMAD3 PSer208	dephosphorylation down-regulates ⊣	SMAD3	17035229	SIGNOR-248307
CTDSPL	dephosphorylation down-regulates ⊣	SMAD3 PSer213	dephosphorylation down-regulates ⊣	SMAD3	17035229	SIGNOR-248308
CTDSPL	dephosphorylation down-regulates ⊣	SMAD2 PSer245	dephosphorylation up-regulates →	SMAD2	17035229	SIGNOR-248310
CTDSPL	dephosphorylation down-regulates ⊣	SMAD2 PSer250	dephosphorylation up-regulates →	SMAD2	17035229	SIGNOR-248311
CTDSPL	dephosphorylation down-regulates ⊣	SMAD2 PSer255	dephosphorylation up-regulates →	SMAD2	17035229	SIGNOR-248312
CTDSPL	dephosphorylation down-regulates ⊣	SMAD2 PThr220	dephosphorylation up-regulates →	SMAD2	17035229	SIGNOR-248309
CTDSPL	dephosphorylation down-regulates ⊣	SMAD1 PSer187	dephosphorylation up-regulates →	SMAD1	17085434	SIGNOR-248313
CTDSPL	dephosphorylation down-regulates ⊣	SMAD1 PSer195	dephosphorylation up-regulates →	SMAD1	17085434	SIGNOR-248314
CTDSPL	dephosphorylation down-regulates ⊣	SMAD1 PSer206	dephosphorylation up-regulates →	SMAD1	17085434	SIGNOR-248315
CTDSPL	dephosphorylation down-regulates ⊣	SMAD1 PSer214	dephosphorylation up-regulates →	SMAD1	17085434	SIGNOR-248316

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CTDSPL	dephosphorylation → up-regulates activity	RB1	SIGNOR-248304
CTDSPL	dephosphorylation → up-regulates activity	RB1	SIGNOR-248305
CTDSPL	dephosphorylation → up-regulates activity	SMAD3	SIGNOR-248306
CTDSPL	dephosphorylation → up-regulates activity	SMAD3	SIGNOR-248307
CTDSPL	dephosphorylation → up-regulates activity	SMAD3	SIGNOR-248308
CTDSPL	dephosphorylation → down-regulates activity	SMAD2	SIGNOR-248310
CTDSPL	dephosphorylation → down-regulates activity	SMAD2	SIGNOR-248311
CTDSPL	dephosphorylation → down-regulates activity	SMAD2	SIGNOR-248312
CTDSPL	dephosphorylation → down-regulates activity	SMAD2	SIGNOR-248309
CTDSPL	dephosphorylation → down-regulates activity	SMAD1	SIGNOR-248313
CTDSPL	dephosphorylation → down-regulates activity	SMAD1	SIGNOR-248314
CTDSPL	dephosphorylation → down-regulates activity	SMAD1	SIGNOR-248315
CTDSPL	dephosphorylation → down-regulates activity	SMAD1	SIGNOR-248316