| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | HDAC3 | Ser424 | DHDNDKEsDVEI | dephosphorylation down-regulates activity | 15805470 | SIGNOR-248548 |
| SRC | HDAC3 | Tyr325 | AISEELPySEYFEYF | phosphorylation up-regulates activity | 30317579 | SIGNOR-277484 |
| SRC | HDAC3 | Tyr331 | PYSEYFEyFAPDFTL | phosphorylation up-regulates activity | 30317579 | SIGNOR-277486 |
| CSNK2A1 | HDAC3 | Ser424 | DHDNDKEsDVEI | phosphorylation up-regulates activity | 15805470 | SIGNOR-250889 |
| PINK1 | HDAC3 | Ser424 | DHDNDKEsDVEI | phosphorylation up-regulates activity | 25305081 | SIGNOR-279093 |
| TBK1 | HDAC3 | – | phosphorylation up-regulates activity | 32772249 | SIGNOR-279662 | |
| GSK3B | HDAC3 | – | phosphorylation up-regulates activity | 21289184 | SIGNOR-278400 | |
| SRC | HDAC3 | Tyr328 | EELPYSEyFEYFAPD | phosphorylation up-regulates activity | 30317579 | SIGNOR-277485 |
| HIPK2 | HDAC3 | Ser374 | KMLNHAPsVQIHDVP | phosphorylation down-regulates activity | 34244427 | SIGNOR-277568 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP4C | dephosphorylation down-regulates ⊣ | HDAC3 PSer424 | dephosphorylation up-regulates → | HDAC3 | 15805470 | SIGNOR-248548 |
| SRC | phosphorylation up-regulates → | HDAC3 PTyr325 | phosphorylation up-regulates → | HDAC3 | 30317579 | SIGNOR-277484 |
| SRC | phosphorylation up-regulates → | HDAC3 PTyr331 | phosphorylation up-regulates → | HDAC3 | 30317579 | SIGNOR-277486 |
| CSNK2A1 | phosphorylation up-regulates → | HDAC3 PSer424 | phosphorylation up-regulates → | HDAC3 | 15805470 | SIGNOR-250889 |
| PINK1 | phosphorylation up-regulates → | HDAC3 PSer424 | phosphorylation up-regulates → | HDAC3 | 25305081 | SIGNOR-279093 |
| SRC | phosphorylation up-regulates → | HDAC3 PTyr328 | phosphorylation up-regulates → | HDAC3 | 30317579 | SIGNOR-277485 |
| HIPK2 | phosphorylation up-regulates → | HDAC3 PSer374 | phosphorylation down-regulates ⊣ | HDAC3 | 34244427 | SIGNOR-277568 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP4C | dephosphorylation → down-regulates activity | HDAC3 | SIGNOR-248548 |
| SRC | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-277484 |
| SRC | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-277486 |
| CSNK2A1 | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-250889 |
| PINK1 | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-279093 |
| TBK1 | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-279662 |
| GSK3B | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-278400 |
| SRC | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-277485 |
| HIPK2 | phosphorylation → down-regulates activity | HDAC3 | SIGNOR-277568 |
