Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
LYN	RGS16	Tyr168	TLMEKDSyPRFLKSP	phosphorylation up-regulates activity	12588871	SIGNOR-251410
EGFR	RGS16	Tyr177	RFLKSPAyRDLAAQA	phosphorylation up-regulates	11602604	SIGNOR-111024
EGFR	RGS16	Tyr168	TLMEKDSyPRFLKSP	phosphorylation up-regulates	12588871	SIGNOR-98267
SRC	RGS16	Tyr168	TLMEKDSyPRFLKSP	phosphorylation up-regulates	12588871	SIGNOR-98271
SRC	RGS16	Tyr177	RFLKSPAyRDLAAQA	phosphorylation up-regulates	12588871	SIGNOR-98275

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
LYN	phosphorylation up-regulates →	RGS16 PTyr168	phosphorylation up-regulates →	RGS16	12588871	SIGNOR-251410
EGFR	phosphorylation up-regulates →	RGS16 PTyr177	phosphorylation up-regulates →	RGS16	11602604	SIGNOR-111024
EGFR	phosphorylation up-regulates →	RGS16 PTyr168	phosphorylation up-regulates →	RGS16	12588871	SIGNOR-98267
SRC	phosphorylation up-regulates →	RGS16 PTyr168	phosphorylation up-regulates →	RGS16	12588871	SIGNOR-98271
SRC	phosphorylation up-regulates →	RGS16 PTyr177	phosphorylation up-regulates →	RGS16	12588871	SIGNOR-98275

Regulator	Mechanism/Effect	Target	SIGNOR-ID
LYN	phosphorylation → up-regulates activity	RGS16	SIGNOR-251410
EGFR	phosphorylation → up-regulates	RGS16	SIGNOR-111024
EGFR	phosphorylation → up-regulates	RGS16	SIGNOR-98267
SRC	phosphorylation → up-regulates	RGS16	SIGNOR-98271
SRC	phosphorylation → up-regulates	RGS16	SIGNOR-98275