Entity Details

Name MEFV
ID O15553
Role substrate
Enzymatic Domains
Pyrin 1-92
PROSITE-ProRule
B30.2/SPRY 580-775
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PKN1MEFVSer242
View in OncoXplorer
SGKMRPRsLEVTISTphosphorylation
down-regulates activity		27270401SIGNOR-275461
PKN1MEFVSer208VRLRRNAsSAGRLQGphosphorylation
down-regulates activity		27270401SIGNOR-275462
PKN2MEFVSer242
View in OncoXplorer
SGKMRPRsLEVTISTphosphorylation
down-regulates activity		27270401SIGNOR-275463
PKN2MEFVSer208VRLRRNAsSAGRLQGphosphorylation
down-regulates activity		27270401SIGNOR-275464
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PKN1phosphorylation
up-regulates
→
MEFV
PSer242		phosphorylation
down-regulates
⊣		MEFV27270401SIGNOR-275461
PKN1phosphorylation
up-regulates
→
MEFV
PSer208		phosphorylation
down-regulates
⊣		MEFV27270401SIGNOR-275462
PKN2phosphorylation
up-regulates
→
MEFV
PSer242		phosphorylation
down-regulates
⊣		MEFV27270401SIGNOR-275463
PKN2phosphorylation
up-regulates
→
MEFV
PSer208		phosphorylation
down-regulates
⊣		MEFV27270401SIGNOR-275464
Regulator Mechanism/Effect Target SIGNOR-ID
PKN1phosphorylation
→
down-regulates activity 		MEFVSIGNOR-275461
PKN1phosphorylation
→
down-regulates activity 		MEFVSIGNOR-275462
PKN2phosphorylation
→
down-regulates activity 		MEFVSIGNOR-275463
PKN2phosphorylation
→
down-regulates activity 		MEFVSIGNOR-275464