Entity Details

Name KCNN4
ID O15554
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
NME2KCNN4His358FRQVRLKhRKLREQVphosphorylation
up-regulates		17157250SIGNOR-151130
NME2KCNN4His358FRQVRLKhRKLREQVphosphorylation
up-regulates		18796614SIGNOR-181083
PRKACAKCNN4Ser334KHTRRKEsHAARRHQphosphorylation
down-regulates activity		25274816SIGNOR-276855
PHPT1KCNN4His358FRQVRLKhRKLREQVdephosphorylation
down-regulates activity		18796614SIGNOR-277071
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
NME2phosphorylation
up-regulates
→
KCNN4
PHis358		phosphorylation
up-regulates
→		KCNN417157250SIGNOR-151130
NME2phosphorylation
up-regulates
→
KCNN4
PHis358		phosphorylation
up-regulates
→		KCNN418796614SIGNOR-181083
PRKACAphosphorylation
up-regulates
→
KCNN4
PSer334		phosphorylation
down-regulates
⊣		KCNN425274816SIGNOR-276855
PHPT1dephosphorylation
down-regulates
⊣
KCNN4
PHis358		dephosphorylation
up-regulates
→		KCNN418796614SIGNOR-277071
Regulator Mechanism/Effect Target SIGNOR-ID
NME2phosphorylation
→
up-regulates 		KCNN4SIGNOR-151130
NME2phosphorylation
→
up-regulates 		KCNN4SIGNOR-181083
PRKACAphosphorylation
→
down-regulates activity 		KCNN4SIGNOR-276855
PHPT1dephosphorylation
→
down-regulates activity 		KCNN4SIGNOR-277071