| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NME2 | KCNN4 | His358 | FRQVRLKhRKLREQV | phosphorylation up-regulates | 18796614 | SIGNOR-181083 |
| PHPT1 | KCNN4 | His358 | FRQVRLKhRKLREQV | dephosphorylation down-regulates activity | 18796614 | SIGNOR-277071 |
| NME2 | KCNN4 | His358 | FRQVRLKhRKLREQV | phosphorylation up-regulates | 17157250 | SIGNOR-151130 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NME2 | phosphorylation up-regulates → | KCNN4 PHis358 | phosphorylation up-regulates → | KCNN4 | 18796614 | SIGNOR-181083 |
| PHPT1 | dephosphorylation down-regulates ⊣ | KCNN4 PHis358 | dephosphorylation up-regulates → | KCNN4 | 18796614 | SIGNOR-277071 |
| NME2 | phosphorylation up-regulates → | KCNN4 PHis358 | phosphorylation up-regulates → | KCNN4 | 17157250 | SIGNOR-151130 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NME2 | phosphorylation → up-regulates | KCNN4 | SIGNOR-181083 |
| PHPT1 | dephosphorylation → down-regulates activity | KCNN4 | SIGNOR-277071 |
| NME2 | phosphorylation → up-regulates | KCNN4 | SIGNOR-151130 |
