Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK14	SIAH2	–		phosphorylation up-regulates	17003045	SIGNOR-149890
DYRK2	SIAH2	Ser16	PSANKPCsKQPPPQP	phosphorylation up-regulates	22878263	SIGNOR-198721
DYRK2	SIAH2	Ser28	PQPQHTPsPAAPPAA	phosphorylation up-regulates	22878263	SIGNOR-198725
SRC	SIAH2	–		phosphorylation up-regulates activity	23700162	SIGNOR-279555
DYRK2	SIAH2	Ser68	GGGAGPVsPQHHELT	phosphorylation up-regulates	22878263	SIGNOR-198729
DYRK2	SIAH2	Thr119	PTCRGALtPSIRNLA	phosphorylation up-regulates	22878263	SIGNOR-198733
DYRK2	SIAH2	Thr26	PPPQPQHtPSPAAPP	phosphorylation up-regulates	22878263	SIGNOR-198737

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
DYRK2	phosphorylation up-regulates →	SIAH2 PSer16	phosphorylation up-regulates →	SIAH2	22878263	SIGNOR-198721
DYRK2	phosphorylation up-regulates →	SIAH2 PSer28	phosphorylation up-regulates →	SIAH2	22878263	SIGNOR-198725
DYRK2	phosphorylation up-regulates →	SIAH2 PSer68	phosphorylation up-regulates →	SIAH2	22878263	SIGNOR-198729
DYRK2	phosphorylation up-regulates →	SIAH2 PThr119	phosphorylation up-regulates →	SIAH2	22878263	SIGNOR-198733
DYRK2	phosphorylation up-regulates →	SIAH2 PThr26	phosphorylation up-regulates →	SIAH2	22878263	SIGNOR-198737

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK14	phosphorylation → up-regulates	SIAH2	SIGNOR-149890
DYRK2	phosphorylation → up-regulates	SIAH2	SIGNOR-198721
DYRK2	phosphorylation → up-regulates	SIAH2	SIGNOR-198725
SRC	phosphorylation → up-regulates activity	SIAH2	SIGNOR-279555
DYRK2	phosphorylation → up-regulates	SIAH2	SIGNOR-198729
DYRK2	phosphorylation → up-regulates	SIAH2	SIGNOR-198733
DYRK2	phosphorylation → up-regulates	SIAH2	SIGNOR-198737