Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
RIPK2	MAP2K7	–		phosphorylation up-regulates activity	35115556	SIGNOR-280105
RIPK2	RIPK2	Ser176 View in OncoXplorer	KWRMMSLsQSRSSKS	phosphorylation up-regulates activity	16824733	SIGNOR-229701
RIPK2	MAPK1	–		phosphorylation up-regulates activity	10559258	SIGNOR-279106
RIPK2	IRF5	Ser435	EMFSGELsWSADSIR	phosphorylation up-regulates	22412986	SIGNOR-196520
RIPK2	IRF5	Ser446	DSIRLQIsNPDLKDR	phosphorylation up-regulates	22412986	SIGNOR-196524

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
RIPK2	phosphorylation up-regulates →	RIPK2 PSer176	phosphorylation up-regulates →	RIPK2	16824733	SIGNOR-229701
RIPK2	phosphorylation up-regulates →	IRF5 PSer435	phosphorylation up-regulates →	IRF5	22412986	SIGNOR-196520
RIPK2	phosphorylation up-regulates →	IRF5 PSer446	phosphorylation up-regulates →	IRF5	22412986	SIGNOR-196524

Regulator	Mechanism/Effect	Target	SIGNOR-ID
RIPK2	phosphorylation → up-regulates activity	MAP2K7	SIGNOR-280105
RIPK2	phosphorylation → up-regulates activity	RIPK2	SIGNOR-229701
RIPK2	phosphorylation → up-regulates activity	MAPK1	SIGNOR-279106
RIPK2	phosphorylation → up-regulates	IRF5	SIGNOR-196520
RIPK2	phosphorylation → up-regulates	IRF5	SIGNOR-196524