| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | WDR62 | Ser32 | VPARRGQsSPPPAPP | phosphorylation up-regulates activity | 25501809 | SIGNOR-271712 |
| AURKA | WDR62 | Ser33 | PARRGQSsPPPAPPI | phosphorylation up-regulates activity | 25501809 | SIGNOR-271713 |
| MAPK8 | WDR62 | Thr1053 | PSSSLPQtPEQEKFL | phosphorylation down-regulates quantity by destabilization | 30566428 | SIGNOR-271710 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | WDR62 PSer32 | phosphorylation up-regulates → | WDR62 | 25501809 | SIGNOR-271712 |
| AURKA | phosphorylation up-regulates → | WDR62 PSer33 | phosphorylation up-regulates → | WDR62 | 25501809 | SIGNOR-271713 |
| MAPK8 | phosphorylation up-regulates → | WDR62 PThr1053 | phosphorylation down-regulates ⊣ | WDR62 | 30566428 | SIGNOR-271710 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation → up-regulates activity | WDR62 | SIGNOR-271712 |
| AURKA | phosphorylation → up-regulates activity | WDR62 | SIGNOR-271713 |
| MAPK8 | phosphorylation![]() down-regulates quantity by destabilization | WDR62 | SIGNOR-271710 |