Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PRKD1	SPRY2	Ser112 View in OncoXplorer	APLSRSIsTVSSGSR	phosphorylation down-regulates quantity by destabilization	37045830	SIGNOR-280091
DYRK1A	SPRY2	Thr75	KPAPRPStQHKHERL	phosphorylation down-regulates	18678649	SIGNOR-179828
MKNK1	SPRY2	Ser112 View in OncoXplorer	APLSRSIsTVSSGSR	phosphorylation down-regulates	19864419	SIGNOR-188889
SRC	SPRY2	Tyr55	AIRNTNEyTEGPTVV	phosphorylation up-regulates	15564375	SIGNOR-131189
MKNK1	SPRY2	Ser121	VSSGSRSsTRTSTSS	phosphorylation down-regulates	19864419	SIGNOR-188893

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PRKD1	phosphorylation up-regulates →	SPRY2 PSer112	phosphorylation down-regulates ⊣	SPRY2	37045830	SIGNOR-280091
DYRK1A	phosphorylation up-regulates →	SPRY2 PThr75	phosphorylation down-regulates ⊣	SPRY2	18678649	SIGNOR-179828
MKNK1	phosphorylation up-regulates →	SPRY2 PSer112	phosphorylation down-regulates ⊣	SPRY2	19864419	SIGNOR-188889
SRC	phosphorylation up-regulates →	SPRY2 PTyr55	phosphorylation up-regulates →	SPRY2	15564375	SIGNOR-131189
MKNK1	phosphorylation up-regulates →	SPRY2 PSer121	phosphorylation down-regulates ⊣	SPRY2	19864419	SIGNOR-188893

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PRKD1	phosphorylation down-regulates quantity by destabilization	SPRY2	SIGNOR-280091
DYRK1A	phosphorylation down-regulates	SPRY2	SIGNOR-179828
MKNK1	phosphorylation down-regulates	SPRY2	SIGNOR-188889
SRC	phosphorylation → up-regulates	SPRY2	SIGNOR-131189
MKNK1	phosphorylation down-regulates	SPRY2	SIGNOR-188893