| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | SPRY2 | Ser112 | APLSRSIsTVSSGSR | phosphorylation down-regulates quantity by destabilization | 37045830 | SIGNOR-280091 |
| MKNK1 | SPRY2 | Ser112 | APLSRSIsTVSSGSR | phosphorylation down-regulates | 19864419 | SIGNOR-188889 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | phosphorylation up-regulates → | SPRY2 PSer112 | phosphorylation down-regulates ⊣ | SPRY2 | 37045830 | SIGNOR-280091 |
| MKNK1 | phosphorylation up-regulates → | SPRY2 PSer112 | phosphorylation down-regulates ⊣ | SPRY2 | 19864419 | SIGNOR-188889 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKD1 | phosphorylation![]() down-regulates quantity by destabilization | SPRY2 | SIGNOR-280091 |
| MKNK1 | phosphorylation![]() down-regulates | SPRY2 | SIGNOR-188889 |