Entity Details

Name SNAI2
ID O43623
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PAK4SNAI2Ser254SKTFSRMsLLHKHEEphosphorylation
up-regulates quantity by stabilization		29849120SIGNOR-277394
CyclinE/CDK2SNAI2Ser54ILSSGAYsPITVWTTphosphorylation
down-regulates quantity by destabilization		24662826SIGNOR-276628
PKASNAI2Ser247KYQCKNCsKTFSRMSphosphorylation
down-regulates quantity by destabilization		37596321SIGNOR-277905
PAK4SNAI2–phosphorylation
up-regulates quantity by stabilization		30685413SIGNOR-280057
CyclinE/CDK2SNAI2Ser104
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KDHSGSEsPISDEEEphosphorylation
down-regulates quantity by destabilization		24662826SIGNOR-276629
GSK3BSNAI2–phosphorylation
down-regulates activity		23851495SIGNOR-279414
PAK4SNAI2Ser158CDAQSRKsFSCKYCDphosphorylation
up-regulates quantity by stabilization		29849120SIGNOR-277393
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PAK4phosphorylation
up-regulates
→
SNAI2
PSer254		phosphorylation
up-regulates
→		SNAI229849120SIGNOR-277394
CyclinE/CDK2phosphorylation
up-regulates
→
SNAI2
PSer54		phosphorylation
down-regulates
⊣		SNAI224662826SIGNOR-276628
PKAphosphorylation
up-regulates
→
SNAI2
PSer247		phosphorylation
down-regulates
⊣		SNAI237596321SIGNOR-277905
CyclinE/CDK2phosphorylation
up-regulates
→
SNAI2
PSer104		phosphorylation
down-regulates
⊣		SNAI224662826SIGNOR-276629
PAK4phosphorylation
up-regulates
→
SNAI2
PSer158		phosphorylation
up-regulates
→		SNAI229849120SIGNOR-277393
Regulator Mechanism/Effect Target SIGNOR-ID
PAK4phosphorylation
→
up-regulates quantity by stabilization 		SNAI2SIGNOR-277394
CyclinE/CDK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SNAI2SIGNOR-276628
PKAphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SNAI2SIGNOR-277905
PAK4phosphorylation
→
up-regulates quantity by stabilization 		SNAI2SIGNOR-280057
CyclinE/CDK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SNAI2SIGNOR-276629
GSK3Bphosphorylation
→
down-regulates activity 		SNAI2SIGNOR-279414
PAK4phosphorylation
→
up-regulates quantity by stabilization 		SNAI2SIGNOR-277393