| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinY/CDK16 | PRC1 | Thr481 | RRGLAPNtPGKARKL | phosphorylation up-regulates activity | 35449080 | SIGNOR-273013 |
| CyclinE/CDK2 | PRC1 | Thr481 | RRGLAPNtPGKARKL | phosphorylation unknown | 9885575 | SIGNOR-250746 |
| PLK1 | PRC1 | – | phosphorylation down-regulates activity | 22621898 | SIGNOR-279645 | |
| CyclinE/CDK2 | PRC1 | Thr470 | LYGSAPRtPSKRRGL | phosphorylation unknown | 9885575 | SIGNOR-250745 |
| CDK16 | PRC1 | Thr481 | RRGLAPNtPGKARKL | phosphorylation up-regulates activity | 35449080 | SIGNOR-273017 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinY/CDK16 | phosphorylation up-regulates → | PRC1 PThr481 | phosphorylation up-regulates → | PRC1 | 35449080 | SIGNOR-273013 |
| CyclinE/CDK2 | phosphorylation up-regulates → | PRC1 PThr481 | phosphorylation down-regulates ⊣ | PRC1 | 9885575 | SIGNOR-250746 |
| CyclinE/CDK2 | phosphorylation up-regulates → | PRC1 PThr470 | phosphorylation down-regulates ⊣ | PRC1 | 9885575 | SIGNOR-250745 |
| CDK16 | phosphorylation up-regulates → | PRC1 PThr481 | phosphorylation up-regulates → | PRC1 | 35449080 | SIGNOR-273017 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinY/CDK16 | phosphorylation → up-regulates activity | PRC1 | SIGNOR-273013 |
| CyclinE/CDK2 | phosphorylation → unknown | PRC1 | SIGNOR-250746 |
| PLK1 | phosphorylation → down-regulates activity | PRC1 | SIGNOR-279645 |
| CyclinE/CDK2 | phosphorylation → unknown | PRC1 | SIGNOR-250745 |
| CDK16 | phosphorylation → up-regulates activity | PRC1 | SIGNOR-273017 |
