Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PLK1	PRC1	–		phosphorylation down-regulates activity	22621898	SIGNOR-279645
CyclinE/CDK2	PRC1	Thr481 View in OncoXplorer	RRGLAPNtPGKARKL	phosphorylation unknown	9885575	SIGNOR-250746
CDK16	PRC1	Thr481 View in OncoXplorer	RRGLAPNtPGKARKL	phosphorylation up-regulates activity	35449080	SIGNOR-273017
CyclinY/CDK16	PRC1	Thr481 View in OncoXplorer	RRGLAPNtPGKARKL	phosphorylation up-regulates activity	35449080	SIGNOR-273013
CyclinE/CDK2	PRC1	Thr470 View in OncoXplorer	LYGSAPRtPSKRRGL	phosphorylation unknown	9885575	SIGNOR-250745

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinE/CDK2	phosphorylation up-regulates →	PRC1 PThr481	phosphorylation down-regulates ⊣	PRC1	9885575	SIGNOR-250746
CDK16	phosphorylation up-regulates →	PRC1 PThr481	phosphorylation up-regulates →	PRC1	35449080	SIGNOR-273017
CyclinY/CDK16	phosphorylation up-regulates →	PRC1 PThr481	phosphorylation up-regulates →	PRC1	35449080	SIGNOR-273013
CyclinE/CDK2	phosphorylation up-regulates →	PRC1 PThr470	phosphorylation down-regulates ⊣	PRC1	9885575	SIGNOR-250745

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PLK1	phosphorylation → down-regulates activity	PRC1	SIGNOR-279645
CyclinE/CDK2	phosphorylation → unknown	PRC1	SIGNOR-250746
CDK16	phosphorylation → up-regulates activity	PRC1	SIGNOR-273017
CyclinY/CDK16	phosphorylation → up-regulates activity	PRC1	SIGNOR-273013
CyclinE/CDK2	phosphorylation → unknown	PRC1	SIGNOR-250745