| Name | BUB1 |
| ID | O43683 |
| Role | kinase |
| Enzymatic Domains |
BUB1 N-terminal 11-182 PROSITE-ProRule
Protein kinase 787-1085 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BUB1 | BUB1 | Ser969 | FTAKCETsGFQCVEM | phosphorylation up-regulates activity | 26658523 | SIGNOR-277186 |
| BUB1 | TP53 | Ser37 | NVLSPLPsQAMDDLM | phosphorylation up-regulates activity | 22852086 | SIGNOR-280199 |
| BUB1 | H2AC11 | Thr121 | AVLLPKKtESHHKAK | phosphorylation unknown | 19965387 | SIGNOR-265261 |
| BUB1 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 34852826 | SIGNOR-280198 |
| BUB1 | CDC20 | Ser153 | NRLKVLYsQKATPGS | phosphorylation down-regulates activity | 15525512 | SIGNOR-250604 |
| BUB1 | CDC20 | Ser161 | QKATPGSsRKTCRYI | phosphorylation down-regulates activity | 15525512 | SIGNOR-250605 |
| BUB1 | CDC20 | Ser41 | EAAGPAPsPMRAANR | phosphorylation down-regulates activity | 15525512 | SIGNOR-250606 |
| BUB1 | CDC20 | Ser72 | SKVQTTPsKPGGDRY | phosphorylation down-regulates activity | 15525512 | SIGNOR-250607 |
| BUB1 | CDC20 | Ser92 | AAQMEVAsFLLSKEN | phosphorylation down-regulates activity | 15525512 | SIGNOR-250608 |
| BUB1 | CDC20 | Thr157 | VLYSQKAtPGSSRKT | phosphorylation down-regulates activity | 15525512 | SIGNOR-250609 |
| BUB1 | SGO1 | – | phosphorylation up-regulates quantity by stabilization | 19015261 | SIGNOR-278915 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BUB1 | phosphorylation up-regulates → | BUB1 PSer969 | phosphorylation up-regulates → | BUB1 | 26658523 | SIGNOR-277186 |
| BUB1 | phosphorylation up-regulates → | TP53 PSer37 | phosphorylation up-regulates → | TP53 | 22852086 | SIGNOR-280199 |
| BUB1 | phosphorylation up-regulates → | H2AC11 PThr121 | phosphorylation down-regulates ⊣ | H2AC11 | 19965387 | SIGNOR-265261 |
| BUB1 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 34852826 | SIGNOR-280198 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer153 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250604 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer161 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250605 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer41 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250606 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer72 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250607 |
| BUB1 | phosphorylation up-regulates → | CDC20 PSer92 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250608 |
| BUB1 | phosphorylation up-regulates → | CDC20 PThr157 | phosphorylation down-regulates ⊣ | CDC20 | 15525512 | SIGNOR-250609 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| BUB1 | phosphorylation → up-regulates activity | BUB1 | SIGNOR-277186 |
| BUB1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-280199 |
| BUB1 | phosphorylation → unknown | H2AC11 | SIGNOR-265261 |
| BUB1 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-280198 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250604 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250605 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250606 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250607 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250608 |
| BUB1 | phosphorylation → down-regulates activity | CDC20 | SIGNOR-250609 |
| BUB1 | phosphorylation → up-regulates quantity by stabilization | SGO1 | SIGNOR-278915 |