| Name | BUB1 |
| ID | O43683 |
| Role | substrate |
| Enzymatic Domains |
BUB1 N-terminal 11-182 PROSITE-ProRule
Protein kinase 787-1085 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | BUB1 | – | phosphorylation up-regulates activity | 25540073 | SIGNOR-279251 | |
| BUB1 | BUB1 | Ser969 | FTAKCETsGFQCVEM | phosphorylation up-regulates activity | 26658523 | SIGNOR-277186 |
| TTK | BUB1 | Thr461 | SKVQPSPtVHTKEAL | phosphorylation up-regulates activity | 28072388 | SIGNOR-278255 |
| CDK1 | BUB1 | Thr609 | SAAQLAStPFHKLPV | phosphorylation up-regulates | 16760428 | SIGNOR-147065 |
| ATM | BUB1 | Ser314 | SHEDLPAsQERSEVN | phosphorylation up-regulates | 22099307 | SIGNOR-177276 |
| AURKB | BUB1 | – | phosphorylation up-regulates activity | 34861183 | SIGNOR-279010 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| BUB1 | phosphorylation up-regulates → | BUB1 PSer969 | phosphorylation up-regulates → | BUB1 | 26658523 | SIGNOR-277186 |
| TTK | phosphorylation up-regulates → | BUB1 PThr461 | phosphorylation up-regulates → | BUB1 | 28072388 | SIGNOR-278255 |
| CDK1 | phosphorylation up-regulates → | BUB1 PThr609 | phosphorylation up-regulates → | BUB1 | 16760428 | SIGNOR-147065 |
| ATM | phosphorylation up-regulates → | BUB1 PSer314 | phosphorylation up-regulates → | BUB1 | 22099307 | SIGNOR-177276 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates activity | BUB1 | SIGNOR-279251 |
| BUB1 | phosphorylation → up-regulates activity | BUB1 | SIGNOR-277186 |
| TTK | phosphorylation → up-regulates activity | BUB1 | SIGNOR-278255 |
| CDK1 | phosphorylation → up-regulates | BUB1 | SIGNOR-147065 |
| ATM | phosphorylation → up-regulates | BUB1 | SIGNOR-177276 |
| AURKB | phosphorylation → up-regulates activity | BUB1 | SIGNOR-279010 |