Entity Details

Name ACTN4
ID O43707
Role substrate
Enzymatic Domains
Calponin-homology (CH) 1 50-154
PROSITE-ProRule
Calponin-homology (CH) 2 163-269
PROSITE-ProRule
EF-hand 1 765-800
PROSITE-ProRule
EF-hand 2 806-841
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTK2ACTN4Tyr31GGGSMGDyMAQEDDWphosphorylation
down-regulates		23454549SIGNOR-192195
PTK2ACTN4Tyr265
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MTYVSSFyHAFSGAQphosphorylation
up-regulates		23454549SIGNOR-192191
PTK2ACTN4Tyr4yHAANQSYphosphorylation
down-regulates		23454549SIGNOR-192199
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTK2phosphorylation
up-regulates
→
ACTN4
PTyr31		phosphorylation
down-regulates
⊣		ACTN423454549SIGNOR-192195
PTK2phosphorylation
up-regulates
→
ACTN4
PTyr265		phosphorylation
up-regulates
→		ACTN423454549SIGNOR-192191
PTK2phosphorylation
up-regulates
→
ACTN4
PTyr4		phosphorylation
down-regulates
⊣		ACTN423454549SIGNOR-192199
Regulator Mechanism/Effect Target SIGNOR-ID
PTK2phosphorylation
img/direct_inhibition.png
down-regulates 		ACTN4SIGNOR-192195
PTK2phosphorylation
→
up-regulates 		ACTN4SIGNOR-192191
PTK2phosphorylation
img/direct_inhibition.png
down-regulates 		ACTN4SIGNOR-192199