Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
DYRK3	AKT1S1	–		phosphorylation down-regulates	23415227	SIGNOR-201002
DYRK3	AKT1S1	Thr246	LPRPRLNtSDFQKLK	phosphorylation down-regulates activity	23415227	SIGNOR-279167
DYRK3	SIRT1	–		phosphorylation up-regulates activity	20167603	SIGNOR-279705
DYRK3	NCOA3	Ser1330	PAFGRVSsPPNAMMS	phosphorylation down-regulates activity	31066068	SIGNOR-275451
DYRK3	mTORC1	–		phosphorylation down-regulates	23415227	SIGNOR-217571

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
DYRK3	phosphorylation up-regulates →	AKT1S1 PThr246	phosphorylation down-regulates ⊣	AKT1S1	23415227	SIGNOR-279167
DYRK3	phosphorylation up-regulates →	NCOA3 PSer1330	phosphorylation down-regulates ⊣	NCOA3	31066068	SIGNOR-275451

Regulator	Mechanism/Effect	Target	SIGNOR-ID
DYRK3	phosphorylation down-regulates	AKT1S1	SIGNOR-201002
DYRK3	phosphorylation → down-regulates activity	AKT1S1	SIGNOR-279167
DYRK3	phosphorylation → up-regulates activity	SIRT1	SIGNOR-279705
DYRK3	phosphorylation → down-regulates activity	NCOA3	SIGNOR-275451
DYRK3	phosphorylation down-regulates	mTORC1	SIGNOR-217571