Entity Details

Name SPOP
ID O43791
Role substrate
Enzymatic Domains
MATH 31-161
PROSITE-ProRule
BTB 173-297
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LIMK2SPOPSer226AARSPVFsAMFEHEMphosphorylation
down-regulates activity		33311589SIGNOR-278338
LIMK2SPOPSer171VQDSVNIsGQNTMNMphosphorylation
down-regulates activity		33311589SIGNOR-278339
LIMK2SPOPSer59IKSSTFSsGANDKLKphosphorylation
down-regulates activity		33311589SIGNOR-278337
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LIMK2phosphorylation
up-regulates
→
SPOP
PSer226		phosphorylation
down-regulates
⊣		SPOP33311589SIGNOR-278338
LIMK2phosphorylation
up-regulates
→
SPOP
PSer171		phosphorylation
down-regulates
⊣		SPOP33311589SIGNOR-278339
LIMK2phosphorylation
up-regulates
→
SPOP
PSer59		phosphorylation
down-regulates
⊣		SPOP33311589SIGNOR-278337
Regulator Mechanism/Effect Target SIGNOR-ID
LIMK2phosphorylation
→
down-regulates activity 		SPOPSIGNOR-278338
LIMK2phosphorylation
→
down-regulates activity 		SPOPSIGNOR-278339
LIMK2phosphorylation
→
down-regulates activity 		SPOPSIGNOR-278337